Jeanne Rivera
- Email: ed12jfr@leeds.ac.uk
- Thesis title: Molecular regulation of Chk1 kinase in Myeloproliferative Neoplasms
- Supervisors: Edwin Chen, Andrew McDOnald
Profile
I joined University of Leeds in 2013 as an Undergraduate Student and received the BSc degree with Honours in Genetics in 2016.
Following this, I started in Edwin Chen's group as a PhD student in 2016 funded by the Leeds Anniversary Research Scholarships (LARS).
Research interests
My research project aims to understand the molecular pathways that play a pivotal role in the pathogenesis of haematological malignancies. Specifically, the main focus of this project is to investigate mutations of a chaperone protein, calreticulin (CALR) and its role in contributing to development of Myeloproliferative Neoplasms (MPN). Recurrent somatic mutations in exon 9 of the calreticulin (CALR) gene are found in a majority of JAK2-unmutated MPNs. All known mutations result in a +1-frameshift in the CALR reading frame that creates a novel C-terminal domain encoded by an alternative reading frame. The primary goal of this project is to identify key features in the N-domain of mutant CALR required for its oncogenic activity and its therapeutic significance.
Lab Website: https://www.edwinchenlab.com/
Qualifications
- BSc Genetics
Research groups and institutes
- Cancer