Dr Jamel Mankouri
Newly identified factors shown to be important in leading virus entry, survival and release are cellular ion channels, proteins that act as a pore in the membranes of all cells within the body, permitting the selective passage of ions (such as potassium ions, sodium ions, and calcium ions). Through controlling ion passage, these channels serve many critically important cellular functions including chemical signaling, the regulation of pH, and the regulation of cell volume. Malfunction of ion channels can cause diseases in many tissues.
Our research has shown that by pharmacologically modulating cellular ion channels, we can impede the lifecycles of an array of important human viruses. My laboratory focuses on understanding the interaction between viruses and cellular ion channels in more detail. By doing so, we wish to reveal the potential of ion channel modulating compounds (many of which are clinically available) as new anti-viral drugs.
- Identifiying new virus-ion channel interactions.
- Investigating the potential of restoring the function of virus-ion channel targets as a new anti-viral strategy.
- Defining the molecular mechanisms by which viruses require cellular ion channel activity.
- Dynamic visualization of host cell ion channel and viral protein trafficking in virus infected cells.
We apply these studies to negative sense RNA viruses including bunyaviruses, human respiratory syncytial virus and rabies virus.
Career History: Post-doctoral researcher with Prof Mark Harris in the School of Molecular and Cellular Biology, University of Leeds (2006 - 2009); Post-doctoral Researcher with Prof Mark Harris and Dr Stephen Griffin (2009-2011) in the School of Molecular and Cellular Biology, University of Leeds. Royal Society University Research Fellow (2011-present).
- PhD, University of Leeds
- BSc, Pharmacology
Undergraduate project topics:
- Virus-host interactions in zoonotic viruses
- Ion channel modulators as new anti-viral compounds
Postgraduate studentship areas:
- Targeting Ion Channel Function for Rabies Virus Therapy
BIOL2210 - Biological Membranes and Cell Signalling
BIOC1301 - Introductory Integrated Biochemistry: the Molecules and Processes of Life
BIOC3111/12/BIOL3112/MICR3120 A - ATU - Visualising Viruses
BIOC3160 - Laboratory/Literature/Computing Research Project
BIOL2210/BIOC2301 - Integrated Biochemistry/Biological Membranes
BIOL2301/05 - Intermediate Skills - BIOL
BIOL3215 - Cancer Biology
BIOL3398 - Research Tools and Applications
BIOL5296M - Treatment of Infectious Disease and Cancer
BMSC1212 - Introduction to Pharmacology
BMSC2210 - Chemotherapy
FOBS1135/BIOL1112 - The Basis of Life/The molecules of life
MICR1120 - Introduction to Microbiology
MICR2120/BIOC2301 - Integrated Biochemistry/Medical Bacteriology
MICR3110 - Medical Microbiology Research Project
MICR3211 - Advanced Topics in Microbiology 2