Miss Beatriz Álvarez Rodríguez
During my Biochemistry studies at the Universidad Autónoma de Madrid (UAM) I had the opportunity to work at the Centro de Biología Molecular Severo Ochoa in Madrid, where I studied the translational control of viruses supervised by Dr. Iván Ventoso. Keeping on with the research on infectious diseases, I took part in a project based on the in vitro activities of the agent Bedaquiline in non-tuberculous mycobacteria within the Erasmus+ programme, supervised by Prof. Peter Van Damme and Dr. Anandi Martin at the LM-UGent (Belgium).
Subsequently, I decided to start a MSc in Molecular Nanoscience and Nanotechnology coordinated by the Universitat de València in 2016. During this period, I did my master thesis at IMDEA-nanoscience institute under the supervision of Dr. Álvaro Somoza with a grant funded by the UAM. My work there was focused on the development of gold-based nanostructures for uveal melanoma treatment.
My current research project is part of the HONOURs Marie-Curie ITN on host switching pathogens, infectious outbreaks and zoonosis (honours.eu). My research is focused on the structural study of orthonairovirus ribonucleoproteins and the development diagnostic tests to detect them in biological samples using the novel technology of Affimer reagents.
We aim to use electron microscopy and crystallographic techniques for the structural elucidation of the nucleoproteins and the ribonucleoprotein complexes of these viruses. The use of a reverse genetics system, will allow us to engineer clonable tags for purification or labelling of viral proteins, in order to obtain purified viral structures and study the different stages of the viral cycle.
Additionally, we are using antibodies and Affimer reagents targeted to nairoviral nucleoproteins as the detecting molecules of diagnostic tests (ELISA and LFAs) for the detection of viral infections. These studies will help to a better understanding of the biology of zoonotic viruses and will lead to a rapid detection system of emerging viruses, which is a critical component of disease surveillance and management.<h4>Research projects</h4> <p>Any research projects I'm currently working on will be listed below. Our list of all <a href="https://biologicalsciences.leeds.ac.uk/dir/research-projects">research projects</a> allows you to view and search the full list of projects in the faculty.</p>
- MSc Molecular Nanoscience and Nanotechnology
- BSc Biochemistry