Dr Charlie Scarff

Dr Charlie Scarff


I completed my PhD in 2010 at the University of Warwick under the supervision of Prof. Jim Scrivens. My PhD work focussed on the investigation of protein structure by use of mass spectrometry, particularly using ion mobility mass spectrometry to study protein conformation and dynamics. In 2011, I moved to the University of Leeds as a postdoctoral research fellow,  applying structural mass spectrometry to the understanding of amyloid assembly and working with Prof Alison Ashcroft and Prof Sheena Radford FRS. In 2014, I undertook a new postdoctoral position at Leeds working with Prof John Trinick, studying muscle proteins by use of electron microscopy. Through this work an interest in muscle, myosin and inherited heart disease grew and I realised how I could contribute to this research area through an integrative structural biology approach. I was awarded a Wellcome Trust Institutional Strategic Support Fund Fellowship to explore this avenue of research and this now forms the focus of my current BHF fellowship; combining mass-spectrometry and electron-microscopy based approaches to address unanswered questions regarding the structural basis of inherited heart disease.

Research interests

My research interests are in understanding structural-functional relationships in muscle, myosin and inherited heart disease and in developing methods in integrative structural biology. I am paticulary interested in how electron microscopy-based workflows can be combined with mass spectrometry-based workflows to enable increased understanding of macromolecular complexes, their dynamics and heterogeniety. This research will lead to a better understanding of the molecular mechanisms that underpin inherited heart disease, and it is my hope that this will pave the way to better therapies in the future.

<h4>Research projects</h4> <p>Any research projects I'm currently working on will be listed below. Our list of all <a href="https://biologicalsciences.leeds.ac.uk/dir/research-projects">research projects</a> allows you to view and search the full list of projects in the faculty.</p>


  • PhD

Professional memberships

  • Member of the British Biophysical Society
  • Member of the Biochemical Society
  • Member of the British Mass Spectrometry Society
  • Member of the Association of Inherited Cardiac Conditions

Research groups and institutes

  • Cardiovascular
  • Macromolecular Complexes
  • Molecular machinery of muscle contraction
  • Structural Biology
<h4>Postgraduate research opportunities</h4> <p>We welcome enquiries from motivated and qualified applicants from all around the world who are interested in PhD study. Our <a href="https://phd.leeds.ac.uk">research opportunities</a> allow you to search for projects and scholarships.</p>