{"id":"00947100","next":"","publications":{"selected_publication":[{"html":"
Greer SK; Steven JC; Steven D; Christian RB; Janne P; Karolina JJ; Yeni HY; Miguel AC; Snead OC; Bente V; John HP; Martin RR; John CR<\/span> (2011)<\/span> Mania-like behavior induced by genetic dysfunction of the neuron-specific Na\n +<\/sup>\n ,K\n +<\/sup>\n -ATPase \u03b13 sodium pump<\/span>. Proceedings of the National Academy of Sciences<\/span>, 108<\/span>, (44)<\/span>, pp. 18144-18149<\/span>. Clapcote SJ; Duffy S; Xie G; Kirshenbaum G; Bechard AR; Rodacker Schack V; Petersen J; Sinai L; Saab BJ; Lerch JP; Minassian BA; Ackerley CA; Sled JG; Cortez MA; Henderson JT; Vilsen B; Roder JC<\/span> (2009)<\/span> Mutation I810N in the alpha3 isoform of Na+,K+-ATPase causes impairments in the sodium pump and hyperexcitability in the CNS<\/span>. Proc Natl Acad Sci U S A<\/span>, 106<\/span>, (33)<\/span>, pp. 14085-14090<\/span>. Clapcote SJ; Lipina TV; Millar JK; Mackie S; Christie S; Ogawa F; Lerch JP; Trimble K; Uchiyama M; Sakuraba Y; Kaneda H; Shiroishi T; Houslay MD; Henkelman RM; Sled JG; Gondo Y; Porteous DJ; Roder JC<\/span> (2007)<\/span> Behavioral phenotypes of Disc1 missense mutations in mice<\/span>. Neuron<\/span>, 54<\/span>, (3)<\/span>, pp. 387-402<\/span>. Simpson AJ; McLellan A; Behl KE; Brown J; Clapcote SJ; Cross JH; van den Maagdenberg AMJM; Vezyroglou AN; Balestrini S; Sisodiya SM<\/span> (2025)<\/span> Alternating Hemiplegia of Childhood and ATP1A3-Related Diseases: Insights From a Decade of Discovery and Collaboration<\/span>. Neurol Genet<\/span>, 11<\/span>, (5)<\/span>, pp. e200308<\/span>. Pantiru AD; Van de Sompele S; Ligneul C; Chatelain C; Barrea C; Lerch JP; Filippi BM; Alkan S; De Baere E; Johnston J; Clapcote SJ<\/span> (2025)<\/span> Autistic behavior is a common outcome of biallelic disruption of PDZD8 in humans and mice<\/span>. Mol Autism<\/span>, 16<\/span>, (1)<\/span>, pp. 14<\/span>. Lipina TV; Li S; Petrova ES; Amstislavskaya TG; Cameron RT; Elliott C; Gondo Y; McGirr A; Mullins JGL; Baillie GS; Woodgett JR; Clapcote SJ<\/span> (2024)<\/span> PDE4B Missense Variant Increases Susceptibility to Post-traumatic Stress Disorder-Relevant Phenotypes in Mice<\/span>. J Neurosci<\/span>, 44<\/span>, (43)<\/span>, pp. e0137242024<\/span>. Armstrong P; G\u00fcng\u00f6r H; Anongjanya P; Tweedy C; Parkin E; Johnston J; Carr IM; Dawson N; Clapcote SJ<\/span> (2024)<\/span> Protective effect of PDE4B subtype-specific inhibition in an App knock-in mouse model for Alzheimer's disease<\/span>. Neuropsychopharmacology<\/span>, 49<\/span>, (10)<\/span>, pp. 1559-1568<\/span>. Cardno AG; el din SN; Toit DD; Rehman F-U; McIlrae S; Variend H; Hussein N-R; Dasi R; Clapcote SJ; Jones LA; Jones WR; Stephenson C; Shora S; Mahmood T<\/span> (2024)<\/span> Relationships between psychotic and affective symptoms, schizotypal and dissociative phenomena, and adverse life events among individuals with psychotic disorders<\/span>. Journal of Psychiatric Intensive Care<\/span>, 20<\/span>, (1)<\/span>, pp. 9-17<\/span>. Chofflet N; Naito Y; Pastore AJ; Padmanabhan N; Nguyen PT; Poitras C; Feller B; Yi N; Van Prooijen J; Khaled H; Coulombe B; Clapcote SJ; Bourgault S; Siddiqui TJ; Rudenko G; Takahashi H<\/span> (2024)<\/span> Structural and functional characterization of the IgSF21-neurexin2\u03b1 complex and its related signaling pathways in the regulation of inhibitory synapse organization<\/span>. Front Mol Neurosci<\/span>, 17<\/span>, pp. 1371145<\/span>. Wilkinson ID; Mahmood T; Yasmin SF; Tomlinson A; Nazari J; Alhaj H; El Din SN; Neill J; Pandit C; Ashraf S; Cardno AG; Clapcote SJ; Inglehearn CF; Woodruff PW<\/span> (2023)<\/span> In memory of Professor Iain Wilkinson: cognitive and neuroimaging endophenotypes in a consanguineous schizophrenia multiplex family<\/span>. Psychol Med<\/span>, 53<\/span>, (7)<\/span>, pp. 3178-3186<\/span>. Clapcote SJ<\/span> (2022)<\/span> How can we obtain truly translational mouse models to improve clinical outcomes in schizophrenia?<\/span> Dis Model Mech<\/span>, 15<\/span>, (11)<\/span>, pp. dmm049970<\/span>. Al-Amri AH; Armstrong P; Amici M; Ligneul C; Rouse J; El-Asrag ME; Pantiru A; Vancollie VE; Ng HWY; Ogbeta JA; Goodchild K; Ellegood J; Lelliott CJ; Mullins JGL; Bretman A; Al-Ali R; Beetz C; Al-Gazali L; Al Shamsi A; Lerch JP; Mellor JR; Al Sayegh A; Ali M; Inglehearn CF; Clapcote SJ<\/span> (2022)<\/span> PDZD8 Disruption Causes Cognitive Impairment in Humans, Mice, and Fruit Flies<\/span>. Biol Psychiatry<\/span>, 92<\/span>, (4)<\/span>, pp. 323-334<\/span>. Hughes RB; Whittingham-Dowd J; Clapcote SJ; Broughton SJ; Dawson N<\/span> (2022)<\/span> Altered medial prefrontal cortex and dorsal raph\u00e9 activity predict genotype and correlate with abnormal learning behavior in a mouse model of autism-associated 2p16.3 deletion<\/span>. Autism Res<\/span>, 15<\/span>, (4)<\/span>, pp. 614-627<\/span>. Ng HWY; Ogbeta JA; Clapcote SJ<\/span> (2021)<\/span> Genetically altered animal models for ATP1A3-related disorders<\/span>. Dis Model Mech<\/span>, 14<\/span>, (10)<\/span>, pp. dmm048938<\/span>. Hosalli P; Cardno A; Brewin A; Nazari J; Clapcote SJ; Inglehearn CF; Mahmood T<\/span> (2021)<\/span> Risk of psychosis in Yorkshire African, Caribbean and Mixed Ethnic communities<\/span>. Journal of Psychiatric Intensive Care<\/span>, 17<\/span>, (2)<\/span>, pp. 107-111<\/span>. Cole BA; Clapcote SJ; Muench SP; Lippiat JD<\/span> (2021)<\/span> Targeting KNa1.1 channels in KCNT1-associated epilepsy<\/span>. Trends Pharmacol Sci<\/span>, 42<\/span>, (8)<\/span>, pp. 700-713<\/span>. Mahmood T; El-Asrag ME; Poulter JA; Cardno AG; Tomlinson A; Ahmed S; Al-Amri A; Nazari J; Neill J; Chamali RS; Kiwan N; Ghuloum S; Alhaj HA; Randerson Moor J; Khan S; Al-Amin H; Johnson CA; Woodruff P; Wilkinson ID; Ali M; Clapcote SJ; Inglehearn CF<\/span> (2021)<\/span> A Recessively Inherited Risk Locus on Chromosome 13q22-31 Conferring Susceptibility to Schizophrenia<\/span>. Schizophr Bull<\/span>, 47<\/span>, (3)<\/span>, pp. 796-802<\/span>. B Hughes R; Whittingham-Dowd J; Simmons RE; Clapcote SJ; Broughton SJ; Dawson N<\/span> (2020)<\/span> Ketamine Restores Thalamic-Prefrontal Cortex Functional Connectivity in a Mouse Model of Neurodevelopmental Disorder-Associated 2p16.3 Deletion<\/span>. Cereb Cortex<\/span>, 30<\/span>, (4)<\/span>, pp. 2358-2371<\/span>. Al-Amri AH; Al Saegh A; Al-Mamari W; El-Asrag ME; Al-Kindi MN; Al Khabouri M; Al Wardy N; Al Lamki K; Gabr A; Idris A; Inglehearn CF; Clapcote SJ; Ali M<\/span> (2019)<\/span> LHFPL5 mutation: A rare cause of non-syndromic autosomal recessive hearing loss<\/span>. Eur J Med Genet<\/span>, 62<\/span>, (12)<\/span>, pp. 103592<\/span>. Clapcote S; Inglehearn CF; Ali M; Al-Amri AH; Bretman A; Rouse J; Wainwright T; Armstrong P<\/span> (2019)<\/span> Truncation mutation of PDZD8 in a family with intellectual disability and autistic features<\/span>. IBRO Reports<\/span>, 6<\/span>, pp. S94<\/span>. Alsaady I; Tedford E; Alsaad M; Bristow G; Kohli S; Murray M; Reeves M; Vijayabaskar MS; Clapcote SJ; Wastling J; McConkey GA<\/span> (2019)<\/span> Downregulation of the Central Noradrenergic System by Toxoplasma gondii Infection<\/span>. Infect Immun<\/span>, 87<\/span>, (2)<\/span>, pp. e00789-e00718<\/span>. Pervolaraki E; Tyson AL; Pibiri F; Poulter SL; Reichelt AC; Rodgers RJ; Clapcote SJ; Lever C; Andreae LC; Dachtler J<\/span> (2019)<\/span> The within-subject application of diffusion tensor MRI and CLARITY reveals brain structural changes in Nrxn2 deletion mice<\/span>. Mol Autism<\/span>, 10<\/span>, (1)<\/span>, pp. 8<\/span>. Timothy JWS; Klas N; Sanghani HR; Al-Mansouri T; Hughes ATL; Kirshenbaum GS; Brienza V; Belle MDC; Ralph MR; Clapcote SJ; Piggins HD<\/span> (2018)<\/span> Circadian Disruptions in the Myshkin Mouse Model of Mania Are Independent of Deficits in Suprachiasmatic Molecular Clock Function<\/span>. Biol Psychiatry<\/span>, 84<\/span>, (11)<\/span>, pp. 827-837<\/span>. Cheung SY; Henrot M; Al-Saad M; Baumann M; Muller H; Unger A; Rubaiy HN; Mathar I; Dinkel K; Nussbaumer P; Klebl B; Freichel M; Rode B; Trainor S; Clapcote SJ; Christmann M; Waldmann H; Abbas SK; Beech DJ; Vasudev NS<\/span> (2018)<\/span> TRPC4\/TRPC5 channels mediate adverse reaction to the cancer cell cytotoxic agent (-)-Englerin A<\/span>. Oncotarget<\/span>, 9<\/span>, (51)<\/span>, pp. 29634-29643<\/span>. Liu M; Fitzgibbon M; Wang Y; Reilly J; Qian X; O'Brien T; Clapcote S; Shen S; Roche M<\/span> (2018)<\/span> Ulk4 regulates GABAergic signaling and anxiety-related behavior<\/span>. Transl Psychiatry<\/span>, 8<\/span>, (1)<\/span>, pp. 43<\/span>. Al-Amri A; Saegh AA; Al-Mamari W; El-Asrag ME; Ivorra JL; Cardno AG; Inglehearn CF; Clapcote SJ; Ali M<\/span> (2016)<\/span> Homozygous single base deletion in TUSC3 causes intellectual disability with developmental delay in an Omani family<\/span>. Am J Med Genet A<\/span>, 170<\/span>, (7)<\/span>, pp. 1826-1831<\/span>. Kirshenbaum GS; Idris NF; Dachtler J; Roder JC; Clapcote SJ<\/span> (2016)<\/span> Deficits in social behavioral tests in a mouse model of alternating hemiplegia of childhood<\/span>. J Neurogenet<\/span>, 30<\/span>, (1)<\/span>, pp. 42-49<\/span>. McGirr A; Lipina TV; Mun H-S; Georgiou J; Al-Amri AH; Ng E; Zhai D; Elliott C; Cameron RT; Mullins JGL; Liu F; Baillie GS; Clapcote SJ; Roder JC<\/span> (2016)<\/span> Specific Inhibition of Phosphodiesterase-4B Results in Anxiolysis and Facilitates Memory Acquisition<\/span>. Neuropsychopharmacology<\/span>, 41<\/span>, (4)<\/span>, pp. 1080-1092<\/span>. Dachtler J; Elliott C; Rodgers RJ; Baillie GS; Clapcote SJ<\/span> (2016)<\/span>
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