Dr Julie Heggelund
I am a visiting postdoctoral researcher in the group of Professor Adrian Goldman, with a 3-year mobility grant awarded by the Norwegian Research Council. My goal is to solve structures of membrane proteins from M. tuberculosis involved in antimicrobial resistance, using the state-of-the-art equipment available at the Astbury Centre.
My PhD project, supervised by Professor Ute Krengel, focused on the X-ray crystallographic studies of the cholera toxin and the heat-labile enterotoxin. I also investigated the binding of different ligands to the toxins using the methods SPR, ELISA, NMR and MST, including cell biology work. My main findings include five X-ray structures of the cholera toxin binding different blood-group oligosaccharides, complemented by SPR and STD-NMR data (Heggelund et al., PLOS Pathog, 2016, 12(4): e1005567). I spent time as a researcher in the Krengel group after my PhD, working on antibodies involved in cancer immunotherapy.
<h4>Research projects</h4> <p>Any research projects I'm currently working on will be listed below. Our list of all <a href="https://biologicalsciences.leeds.ac.uk/dir/research-projects">research projects</a> allows you to view and search the full list of projects in the faculty.</p>