Dr Lorna Kelly

Profile

I came to the University of Leeds to do my PhD in molecular virology in 2013.  Since completing my PhD I have undertaken postdoctoral research in the Astbury Centre for Structural Biology.

Research interests

My research thus far has focussed on the development of antiviral treatments for two important human diseases:  hepatitis C virus, the leading cause of liver transplantation and liver cancer worldwide; and human parechovirus, a common cause of childhood illnesses with potentially severe complications.  

During my PhD I explored the mechanisms of how different strains, or genotypes, of hepatitis C develop resistance to new antivirals.  I investigated how the virus mutates to escape the actions of antiviral drugs, what effect these mutations have upon its ability to replicate inside cells and how the effectiveness of drugs can depend upon different stages of the virus life cycle.  Following my PhD I then started to test potential inhibitors of human parechovirus which might block the later stages of the virus life cycle, to inhibit its ability to package new virus particles and be released from cells.  

More recently I have used my background in translational virology research to aid the development of viral vectors for gene therapy, exploring the effect upon the production and purification process of vector manufacture, with a view to improving efficiency of vector production and, hence, make these pioneering treatments more widely available.  

<h4>Research projects</h4> <p>Any research projects I'm currently working on will be listed below. Our list of all <a href="https://biologicalsciences.leeds.ac.uk/dir/research-projects">research projects</a> allows you to view and search the full list of projects in the faculty.</p>

Qualifications

  • PhD, University of Leeds
  • BSc (Hons), University of Bristol