Cardiovascular Research

As part of the Cardiovascular and Sport and Exercise Sciences group, we were ranked 1st in the UK for world leading 4* research in the 2014 Research Excellence Framework (REF).

Cardiac arrhythmia

Cardiovascular

Our research

The Cardiovascular group is part of the Cardiovascular and Sport and Exercise Sciences group.

Our research, delivered under six themes, focuses on the function of the heart in health and disease, with additional activity in the area of skeletal muscle. From the level of the single molecule through to the function of the intact heart in vivo, complemented by multi-scale in silico modelling, we deliver world-class research with translational relevance.

We work closely and share three research themes (Skeletal muscle in health and diseaseAgeing and the cardiopulmonary systemExercise and the failing heart) with the Sport and Exercise Sciences (SES) group and use an interdisciplinary approach to answer collective research questions.

We also provide world-class, research-led education through our undergraduate degrees.

Research themes

Molecular machinery of muscle contraction

Contraction of cardiac and skeletal muscle depends on the precise arrangement and interaction of elements of the excitation-contraction machinery and of the signalling pathways that regulate these.

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Cardiac arrhythmia

Cardiac arrhythmias occur when the heart’s electrical activity becomes chaotic and it can no longer pump blood efficiently. Ageing, certain conditions such as heart failure, and even intense exercise training can increase the risk of arrhythmias.

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Cardiac remodelling and repair

Cardiac adaptions through remodelling and repair occur at multiple levels and throughout life. One highly-contested area of research is the extent of myocardial regeneration that takes place following myocardial damage, and the role of stem or progenitor cells in this.

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Skeletal muscle in health and disease

Skeletal muscle is vital for life, underpinning locomotion, respiration, and metabolism, yet we still poorly understand its response to exercise and disease.

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Ageing and the cardiopulmonary system

Age is a major risk factor for the majority of cardiopulmonary complications. In part this is because many cardiovascular and pulmonary diseases are progressive. However, even healthy ageing is associated with a reduction in blood vessel and lung function, with a sharp decline in maximal cardiac output and aerobic capacity as people advance into their 60s and beyond.

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Exercise and the failing heart theme within the Cardiovascular and Sport and Exercise Sciences group

Heart failure is a complex syndrome with impairment of cardiac, respiratory, musculoskeletal and vascular function, all of which contribute to reduced quality of life and mortality. Exercise has established benefits in patients with heart failure but debate continues as to the most appropriate exercise modality.

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Postgraduate research opportunities

We are interested in the brightest and the best students from anywhere in the world to join our research teams. Our current PhD students are funded by research councils (eg Medical Research Council), charities (eg British Heart Foundation), the University, and other sources. If you are interested in undertaking a PhD in our group, we have access to funding streams to support these. We also welcome enquiries from self-funded students.

Our facilities

Head of School for Biomedical Sciences

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Cardiovascular Group Leader

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