Research projects

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Current projects

Title Funder Start date End date
Breaking the Barrier: Mapping protein interactions in the bacterial outer membrane as targets for new antimicrobials Medical Research Council (MRC) 1 March 2024 28 February 2029
Designing sustainable wheat Biotechnology and Biological Sciences Research Council (BBSRC) 1 April 2023 31 March 2028
"NanoRAM: Emerging Nanotools for Soft Matter Characterisation and Manipulation" EU - European Union 1 March 2024 29 February 2028
Host-virus interactions in KSHV-related malignancies: evaluating the role of STIP/HOP as a therapeutic target Medical Research Council (MRC) 1 March 2023 29 February 2028
Antibiotic resistance mediated through allosteric modulation of a drug target (111173 renewal) Royal Society 1 April 2024 31 March 2027
Regulatory mechanisms in myosins Wellcome Trust 1 April 2022 31 March 2027
Regulation of immune signalling via ubiquitin-mediated receptor degradation Wellcome Trust 1 April 2022 31 March 2027
How does Chikungunya virus regulate the switch between genome translation and replication? Medical Research Council (MRC) 1 April 2024 31 March 2027
Delivery and clearance of outer membrane proteins to the bacterial outer membrane Biotechnology and Biological Sciences Research Council (BBSRC) 1 November 2023 31 October 2026
Remodelling of structure-function relationships underlying cardiac dysfunction in ageing and heart failure: A multi-scale systems approach Medical Research Council (MRC) 1 October 2021 30 September 2026
Mass spectrometry infrastructure for in-cell structural biology Wellcome Trust 1 October 2021 30 September 2026
Understanding the role of TAZ in HPV-driven cancers Medical Research Council (MRC) 1 July 2023 30 June 2026
Discovering the genetic drivers for the host resource allocation between symbionts Biotechnology and Biological Sciences Research Council (BBSRC) 1 July 2023 30 June 2026
The GLI Transcription Factors: From Upstream Regulators to Downstream Targets Biotechnology and Biological Sciences Research Council (BBSRC) 1 June 2022 31 May 2026
Defining the role of cell glycocacalyces in cell trafficking at endothelial walls Biotechnology and Biological Sciences Research Council (BBSRC) 1 May 2022 30 April 2026
Why is CFTR required for the multiplication of BK polyomavirus in kidney cells? Kidney Research UK 3 April 2023 2 April 2026
A community-based training programme for cryo-electron microscopy Wellcome Trust 1 April 2021 31 March 2026
Understanding the structural basis of sodium-triggered activation of neuronal potassium channels Biotechnology and Biological Sciences Research Council (BBSRC) 1 April 2023 31 March 2026
Understanding the structural basis of sodium-triggered activation of neuronal potassium channels Biotechnology and Biological Sciences Research Council (BBSRC) 1 April 2023 31 March 2026
In situ architecture of Alzheimer's disease-associated pathology UK Research and Innovation (UKRI) 31 March 2022 30 March 2026
Reengineerng of Oligosaccharide Binding Specificity for Targeted Cellular Delivery Engineering and Physical Sciences Research Council (EPSRC) 1 March 2023 28 February 2026
Understanding and targeting oncogenic biomolecular condensates of ALK kinase Medical Research Council (MRC) 1 March 2023 28 February 2026
Temperature sensitive male fertility; uncovering the mechanisms that make fertility in some species more vulnerable to high temperature Biotechnology and Biological Sciences Research Council (BBSRC) 1 March 2023 28 February 2026
Superselective targeting of cells through multivalent lectin-glycan interactions Biotechnology and Biological Sciences Research Council (BBSRC) 20 February 2023 19 February 2026
Revealing complexity of polysaccharide-protein interactions Biotechnology and Biological Sciences Research Council (BBSRC) 1 February 2023 31 January 2026
Do redox modulated PTMs lead to catalase moonlighting? Leverhulme Trust 1 February 2022 31 January 2026
State of the art electron detection for cyoEM at the Astbury Biostructure Laboratories Wellcome Trust 4 January 2021 3 January 2026
Live cell imaging capability for research on pathogenic viruses Wellcome Trust 4 January 2021 3 January 2026
Royal proteins: role in KSHV RNA processing to novel antiviral approaches Medical Research Council (MRC) 3 January 2023 2 January 2026
Seeing the Unseeable: How Does Protein Dynamic Disorder Shape Biology Royal Society 1 January 2021 31 December 2025
Defining the role of cytokinin in floral duration in barley Biotechnology and Biological Sciences Research Council (BBSRC) 1 January 2023 31 December 2025
Understanding the rules of sample preparation for single particle cryoEM Biotechnology and Biological Sciences Research Council (BBSRC) 1 December 2022 30 November 2025
Does functional 'misfolding' of TonB drive import across the outer membrane? Biotechnology and Biological Sciences Research Council (BBSRC) 7 November 2022 6 November 2025
Persistence Biotechnology and Biological Sciences Research Council (BBSRC) 1 October 2022 30 September 2025
Investigating the Role of SUMOylation in Neural Differentation using CUT&RUN. Royal Society 1 March 2024 31 August 2025
The mechanistic architecture of human action across the lifespan Biotechnology and Biological Sciences Research Council (BBSRC) 14 February 2024 13 August 2025
Network+ AgriFood4NetZero: Plausible Pathways, Practical and Open Science for Net Zero AgriFood Engineering and Physical Sciences Research Council (EPSRC) 1 July 2022 30 June 2025
Structural & Functional Investigations Of A Murderous Enzyme in a Native-like Context Biotechnology and Biological Sciences Research Council (BBSRC) 1 July 2022 30 June 2025
Structural mechanism of DNA damage response on replicating chromatin Medical Research Council (MRC) 1 July 2022 30 June 2025
Abnormal calcium homeostasis as a mechanism of acute diaphragm weakness in sepsis Royal College of Anaesthetists 13 December 2023 12 June 2025
The chaperone cycle of fibroblast growth factor receptor kinases in molecular detail Biotechnology and Biological Sciences Research Council (BBSRC) 1 June 2022 31 May 2025
Regulation of emergency Hematopoiesis by the Ubiquitin-proteasome system National Institute of Health (NIH) 1 September 2021 31 May 2025
The epigenetic control temperature-induced flowering Biotechnology and Biological Sciences Research Council (BBSRC) 16 May 2022 15 May 2025
Structures of full-length FGFR cancer fusions and disease mutants Medical Research Council (MRC) 2 May 2022 1 May 2025
Identifying novel mechano-receptors in the sensory nervous system Biotechnology and Biological Sciences Research Council (BBSRC) 1 May 2022 30 April 2025
Protection and Restoration of mangroves improve biodiversity and livelihoods Department for Environment, Food & Rural Affairs (DEFRA) 1 June 2022 31 March 2025
Characterization of root exudate signals that modulate shoot growth Royal Society 10 March 2023 9 March 2025
The molecular mechanism of DNA double strand break repair in plants Royal Society 1 September 2023 28 February 2025
PIANO - Nanoparticle-Based Imaging and Therapy of Chronic Pain in the Dorsal Root Ganglia (DRG) EU - European Union 1 March 2021 28 February 2025
PDWallMech: Harnessing PlasmoDesma Wall Mechanics for plant biotech and biomaterials UK Research and Innovation (UKRI) 1 February 2021 31 January 2025
Understanding the molecular mechanisms that result in influenza virus pandemics Biotechnology and Biological Sciences Research Council (BBSRC) 1 December 2023 31 January 2025
DRUID:Drivers and Repercussions of UK Insect Declines Natural Environment Research Council (NERC) 4 January 2021 3 January 2025
Establishing why cells accumulate potassium in endosomes Biotechnology and Biological Sciences Research Council (BBSRC) 1 January 2022 31 December 2024
Understanding and managing marine transformations on subtropical reefs Estate of Winifred Violet Scott 1 February 2023 31 December 2024
DELIVER: decarbonising emissions from livestock: innovative valorisation of waste for energy resilience Department for Environment, Food & Rural Affairs (DEFRA) 1 April 2023 30 September 2024
The regulatory roles of the Human Rhinovirus Genome During Early Stages of Infection UK Research and Innovation (UKRI) 1 April 2024 30 September 2024
Towards Innovation of Stented Pericardial Aortic Valves for Transcatheter Implantation Engineering and Physical Sciences Research Council (EPSRC) 1 October 2021 30 September 2024
Unravelling dorsel root ganglion as an intrinsic filtering device Medical Research Council (MRC) 1 September 2021 31 August 2024
Genome-scale functional genomics in Streptomyces species using CRISPR interference Biotechnology and Biological Sciences Research Council (BBSRC) 1 September 2021 31 August 2024
The structural basis of transcription factor 3C recruitment by N-myc Medical Research Council (MRC) 1 September 2021 31 August 2024
Dynamic allostery of Sec machinery in protein transport and folding Biotechnology and Biological Sciences Research Council (BBSRC) 1 May 2020 31 July 2024
Super-resolution imaging across the Biosciences Biotechnology and Biological Sciences Research Council (BBSRC) 1 August 2023 31 July 2024
Targeting transfer RNA-derived fragments during KSHV infection Medical Research Council (MRC) 1 August 2021 31 July 2024
Are pollen sterols in the floral landscape limiting nutrients for wild bees in the UK Natural Environment Research Council (NERC) 1 July 2021 30 June 2024
Modulation of antibiotic resistance and protein synthesis by disrupting Elongation Factor G dynamics Biotechnology and Biological Sciences Research Council (BBSRC) 1 July 2021 30 June 2024
Multiscale analysis of extracellular regulation of BMB signalling Biotechnology and Biological Sciences Research Council (BBSRC) 1 July 2021 30 June 2024

Past projects

Title Funder Start date End date
Structure:Function Correlation in the Human DNA Repair Factor CtIP Biotechnology and Biological Sciences Research Council (BBSRC) 1 June 2021 31 May 2024
Understanding adaptation to increase temperature robustness in wheat Medical Research Council (MRC) 1 October 2019 30 April 2024
Divide and Rule: Localised Ca2+ signalling in sensory neurons Biotechnology and Biological Sciences Research Council (BBSRC) 1 May 2021 30 April 2024
Mitotic spindle stability and chromosome missegregation in cancer Cancer Research UK 1 May 2019 30 April 2024
Insulin sensing in the brain Medical Research Council (MRC) 1 April 2019 31 March 2024
A standalone cyclase of non-ribosomal peptides Biotechnology and Biological Sciences Research Council (BBSRC) 15 March 2021 14 March 2024
Conditional uORF-Dependent Translational Control of Plant Gene Expression Biotechnology and Biological Sciences Research Council (BBSRC) 15 March 2021 14 March 2024
Collaborative research on the role of Haplns as a new class of synaptic organizers Royal Society 10 March 2021 9 March 2024
Multisensory integration: Satiety and olfaction Medical Research Council (MRC) 7 March 2021 6 March 2024
Technology for high-throughput binding assays and screens Medical Research Council (MRC) 27 July 2023 29 February 2024
Life History & genetic strategies of corals in marginal systems Royal Society 1 March 2022 29 February 2024
Peripheral gate in somatosensory system Wellcome Trust 1 March 2019 29 February 2024
Imaging the interactome Leverhulme Trust 1 November 2020 31 October 2023
NIHR FAST - Vivisco National Institute of Health (NIH) 1 May 2023 31 October 2023
Essential ionic triggers for enveloped virus entry Medical Research Council (MRC) 1 November 2020 31 October 2023
Virus manipulation of host non-coding RNA regulatory networks Biotechnology and Biological Sciences Research Council (BBSRC) 1 November 2020 31 October 2023
Molecular mechanisms underpinning nuclear pore permselectivity - A polymer physics approach Royal Society 14 December 2020 31 August 2023
Understanding how proteins are organised in the Z-disk, a super-resolution approach Biotechnology and Biological Sciences Research Council (BBSRC) 1 September 2019 31 August 2023
GENADAPT: Genotypic & Environmental Adaptation through Data Driven Prediction Techniques Biotechnology and Biological Sciences Research Council (BBSRC) 29 July 2022 28 July 2023
Developing novel tools to target the cytoskeleton in health and disease: a UK-Australia collaboration Biotechnology and Biological Sciences Research Council (BBSRC) 1 July 2020 30 June 2023
Understanding the mechanisms underlying myosinopathies Medical Research Council (MRC) 1 July 2019 15 June 2023
Understanding hyaluronan crosslinking mechanisms in ovulation and inflammation: CryoEM structural and interaction analysis of HC-HA/PTX3 complexes Biotechnology and Biological Sciences Research Council (BBSRC) 1 December 2019 8 June 2023
NERC-FAPESP UPskilling and upscaling Brazilian weather Radar for the study of Aerial INsects 1 August 2021 31 May 2023
US Partnering award - Systems biology approaches to animal welfare nexus Biotechnology and Biological Sciences Research Council (BBSRC) 1 June 2018 31 May 2023
HPV hijacking of EGFR via its oncogenic ion channel, the E5 viroporin: a new paradigm for virus-driven carcinogenesis Medical Research Council (MRC) 7 January 2019 6 January 2023
Towards the development of entry inhibitors of BK polyomavirus to treat PVAN Kidney Research UK 1 October 2018 31 March 2022
RiboCode - Unlocking the secrets of specialised ribosomes across eukaryotes Biotechnology and Biological Sciences Research Council (BBSRC) 1 January 2023 -
Predicting population change under thermal stress. Department of Agriculture, Environment and Rural Affairs (DAERA) 1 October 2014 01/10/2017
InSAFE: Securing the Future of the UK's Insect Farming Industry Innovate UK and BBSRC September 2023 August 2025
AKI-Predict: The use of an artificial intelligence-based prediction device in clinical practice for the early prediction of acute kidney injury Kidney Research UK 1st April 2024 31st March 2027