Miao Wang

What is your research project on and why is it important? 

My project was focusing on investigating the oncogenic role of LASP1 in human papillomaviruses (HPV) positive cervical cancers. Persistent infection with high-risk human papillomaviruses is the main cause of a wide range of human cancers, including most cervical cancer and an increasing number of oral cancers. Although the prophylactic vaccines for HPV have already existed, they cannot provide full protection against the viral infection and is not a cure for HPV infection. Preliminary data from our lab demonstrated that LASP1 is involved in the progression of HPV+ cancers. I am using cutting-edge technologies to investigate the mechanism by which LASP1 contributes to the progression of HPV+ cervical cancers, facilitating the development of small molecule drugs to treat HPV+ cervical cancers via targeting LASP1. 

What facilities and specialist equipment do you use to help you carry out your research? 

I used cell culture facilities, qPCR machine, Syngene G:BOX Chemi and Confocal Microscopy and so on to enable me to conduct a thorough investigation into the roles of LASP1 in HPV-related cervical cancer. 

What do you particularly enjoy about your research? 

I value the creative freedom that research provides. Designing experiments, interpreting results, and formulating new hypotheses allow me to think critically and creatively. This freedom to explore different avenues and follow my curiosity is one of the most satisfying aspects of my work. 

Why did you choose to undertake a PhD at the University of Leeds? 

I chose to undertake a PhD at the University of Leeds because of its strong reputation for research excellence, world-class faculty, state-of-the-art facilities, and a collaborative, interdisciplinary research environment. The supportive academic community, vibrant city life, and excellent career prospects further solidified my decision, making Leeds the ideal place to pursue my doctoral studies in cancer biology. 

Who are your supervisors? How have they helped you with your research so far? 

My PhD research has been guided by Prof. Andrew Macdonald at the University of Leeds. He has been instrumental in shaping my research and providing the support I need to succeed. Through regular meetings, he has provided constructive feedback on my experiments, data analysis, and writing. His insights has been invaluable in ensuring that my research stays focused and progresses efficiently. 

What are your plans after you complete your PhD? 

After completing my PhD, I transitioned into a postdoctoral position at the University of Leeds, where I am continuing to build on my research in virology. My long-term goal is to pursue a career in academia, where I can contribute to scientific knowledge, mentor the next generation of researchers, and develop innovative approaches to understanding and treating viral infection. 

Any links we can use for publications and comms about your work 

https://scholar.google.com/citations?user=Tta-6usAAAAJ&hl=en