Research projects

Project title
"NanoRAM: Emerging Nanotools for Soft Matter Characterisation and Manipulation"
Abnormal calcium homeostasis as a mechanism of acute diaphragm weakness in sepsis
A community-based training programme for cryo-electron microscopy
AKI-Predict: The use of an artificial intelligence-based prediction device in clinical practice for the early prediction of acute kidney injury
Antibiotic resistance mediated through allosteric modulation of a drug target (111173 renewal)
Are pollen sterols in the floral landscape limiting nutrients for wild bees in the UK
A standalone cyclase of non-ribosomal peptides
Breaking the Barrier: Mapping protein interactions in the bacterial outer membrane as targets for new antimicrobials
Characterisation of a novel role for PKR in inhibiting virus assembly
Characterization of root exudate signals that modulate shoot growth
Collaborative research on the role of Haplns as a new class of synaptic organizers
Conditional uORF-Dependent Translational Control of Plant Gene Expression
Contagious by Nature: Understanding Optimisation of Social Networks in Wild Populations
Defining the role of cell glycocacalyces in cell trafficking at endothelial walls
Defining the role of cytokinin in floral duration in barley
DELIVER: decarbonising emissions from livestock: innovative valorisation of waste for energy resilience
Delivery and clearance of outer membrane proteins to the bacterial outer membrane
Designing sustainable wheat
Developing novel tools to target the cytoskeleton in health and disease: a UK-Australia collaboration
Discovering the genetic drivers for the host resource allocation between symbionts
Divide and Rule: Localised Ca2+ signalling in sensory neurons
Does functional 'misfolding' of TonB drive import across the outer membrane?
Do redox modulated PTMs lead to catalase moonlighting?
DRUID:Drivers and Repercussions of UK Insect Declines
Dynamic allostery of Sec machinery in protein transport and folding
Essential ionic triggers for enveloped virus entry
Establishing why cells accumulate potassium in endosomes
GENADAPT: Genotypic & Environmental Adaptation through Data Driven Prediction Techniques
Genome-scale functional genomics in Streptomyces species using CRISPR interference
High-thoughput Behavioural Phenotyping to Identify Small Molecule Biologics for the Treatment of Neurological Disorders
Host-virus interactions in KSHV-related malignancies: evaluating the role of STIP/HOP as a therapeutic target
How does Chikungunya virus regulate the switch between genome translation and replication?
How does Chikungunya virus regulate the switch between genome translation and replication?
HPV hijacking of EGFR via its oncogenic ion channel, the E5 viroporin: a new paradigm for virus-driven carcinogenesis
Identifying novel mechano-receptors in the sensory nervous system
Imaging the interactome
Improving seedling vigour through a mechanistic understanding of seed DNA damage responses
InSAFE: Securing the Future of the UK's Insect Farming Industry
In situ architecture of Alzheimer's disease-associated pathology
Insulin sensing in the brain
Investigating the Role of SUMOylation in Neural Differentation using CUT&RUN.
Investigating the Role of SUMOylation in Neural Differentation using CUT&RUN.
Life History & genetic strategies of corals in marginal systems
Live cell imaging capability for research on pathogenic viruses
Mass spectrometry infrastructure for in-cell structural biology
Mitotic spindle stability and chromosome missegregation in cancer
Modulation of antibiotic resistance and protein synthesis by disrupting Elongation Factor G dynamics
Molecular grammar of SurA-client interactions in the periplasm of gram-negative bacteria
Molecular mechanisms underpinning nuclear pore permselectivity - A polymer physics approach
Multiscale analysis of extracellular regulation of BMB signalling
Multisensory integration: Satiety and olfaction
NERC-FAPESP UPskilling and upscaling Brazilian weather Radar for the study of Aerial INsects
Network+ AgriFood4NetZero: Plausible Pathways, Practical and Open Science for Net Zero AgriFood
NIHR FAST - Vivisco
PDWallMech: Harnessing PlasmoDesma Wall Mechanics for plant biotech and biomaterials
Peripheral gate in somatosensory system
Persistence
PIANO - Nanoparticle-Based Imaging and Therapy of Chronic Pain in the Dorsal Root Ganglia (DRG)
Predicting population change under thermal stress.
Protection and Restoration of mangroves improve biodiversity and livelihoods
Reengineerng of Oligosaccharide Binding Specificity for Targeted Cellular Delivery
Regulation of emergency Hematopoiesis by the Ubiquitin-proteasome system
Regulation of immune signalling via ubiquitin-mediated receptor degradation
Regulatory mechanisms in myosins
Remodelling of structure-function relationships underlying cardiac dysfunction in ageing and heart failure: A multi-scale systems approach
Revealing complexity of polysaccharide-protein interactions
RiboCode - Unlocking the secrets of specialised ribosomes across eukaryotes
Royal proteins: role in KSHV RNA processing to novel antiviral approaches
Seeing the Unseeable: How Does Protein Dynamic Disorder Shape Biology
State of the art electron detection for cyoEM at the Astbury Biostructure Laboratories
Structural & Functional Investigations Of A Murderous Enzyme in a Native-like Context
Structural mechanism of DNA damage response on replicating chromatin
Structure:Function Correlation in the Human DNA Repair Factor CtIP
Structures of full-length FGFR cancer fusions and disease mutants
Super-resolution imaging across the Biosciences
Superselective targeting of cells through multivalent lectin-glycan interactions
Targeting transfer RNA-derived fragments during KSHV infection
Technology for high-throughput binding assays and screens
Temperature sensitive male fertility; uncovering the mechanisms that make fertility in some species more vulnerable to high temperature
The chaperone cycle of fibroblast growth factor receptor kinases in molecular detail
The epigenetic control temperature-induced flowering
The GLI Transcription Factors: From Upstream Regulators to Downstream Targets
The mechanistic architecture of human action across the lifespan
The mechanistic architecture of human action across the lifespan
The molecular mechanism of DNA double strand break repair in plants
The molecular mechanism of DNA double strand break repair in plants
The regulatory roles of the Human Rhinovirus Genome During Early Stages of Infection
The regulatory roles of the Human Rhinovirus Genome During Early Stages of Infection
The structural basis of transcription factor 3C recruitment by N-myc
Towards Innovation of Stented Pericardial Aortic Valves for Transcatheter Implantation
Towards the development of entry inhibitors of BK polyomavirus to treat PVAN
Understanding adaptation to increase temperature robustness in wheat
Understanding and managing marine transformations on subtropical reefs
Understanding and targeting oncogenic biomolecular condensates of ALK kinase
Understanding how proteins are organised in the Z-disk, a super-resolution approach
Understanding hyaluronan crosslinking mechanisms in ovulation and inflammation: CryoEM structural and interaction analysis of HC-HA/PTX3 complexes
Understanding the mechanisms underlying myosinopathies
Understanding the molecular mechanisms that result in influenza virus pandemics
Understanding the role of TAZ in HPV-driven cancers
Understanding the rules of sample preparation for single particle cryoEM
Understanding the structural basis of sodium-triggered activation of neuronal potassium channels
Understanding the structural basis of sodium-triggered activation of neuronal potassium channels
Unravelling dorsel root ganglion as an intrinsic filtering device
US Partnering award - Systems biology approaches to animal welfare nexus
Virus manipulation of host non-coding RNA regulatory networks
Why is CFTR required for the multiplication of BK polyomavirus in kidney cells?