Dr Qian Wu

Profile

After completing my undergraduate degree in Biochemistry at the University of Bristol, I pursued my PhD and postdoctoral training in structural biology at the University of Cambridge, within Prof. Sir Tom Blundell's group. During my PhD, I determined the structure and function of essential protein complexes in the non-homologous end joining (NHEJ) pathway, which is one of two major repair pathways for human DNA double-strand breaks. For my postdoc work, I developed a keen interest in studying DDR protein complexes, such as those related to BRCA1, which are involved in the earlier stages of DNA damage response. In September 2018, I was awarded a University Academic Fellowship to establish my independent research group in Leeds, and I was promoted to Associate Professor in 2023. 

Research interests

My research group studies the fundamental mechanisms by which cells respond to and manage DNA damage. Human cells continually face threats from both external and internal sources. DNA damage, one of the most critical forms of injury, can lead to cell death and genome instability, contributing to diseases such as cancer, neurodegenerative disorders, and the aging process. It is vital to maintain the integrity of the genetic information stored in DNA through various damage response and repair signaling pathways, as this is crucial for cellular function and survival. Our focus is on investigting the structures and functions of key protein complexes involved in DNA damage response (DDR) and repair. By utilizing a combination of biochemical, biophysical methods, and cellular studies, we aim to unravel the exact mechanisms that govern human DDR and repair networks.  Our research is funded by several organizations, including UKRI, the Academy of Medical Sciences, and the Wellcome Trust.

We firmly believe that a fundamental value of basic biomedical research is its potential to translate into tools and treatments that enhance human health. In this study, we aim to understand how these pathways malfunction in cancer cells compared to normal cells. This understanding will help us identify suitable targets for developing small molecule compounds that can modulate the DNA damage response and repair signaling. Ultimately, our goal is to aid in future drug discovery and medical applications, specifically to target and kill cancer cells.

• Structural mechanism of DNA damage response on replicating chromatin

Qualifications

• Postdoc, University of Cambridge
• PhD, Structural biology, University of Cambridge
• BSc,Biochemistry, University of Bristol

Professional memberships

• Biochemistry Society

Student education

I deliver lectures on DNA damage response to second and third-year undergraduate students. I am also module manager for Biol3399 for MBIOL students.

Research groups and institutes

• Cancer