Dr Yvonne Nyathi

Research interests

Maintaining cellular protein homeostasis [proteostasis] is crucial for overall cell health and adaptation to stress. Disruptions in proteostasis, caused by factors like aging or genetic mutations, can lead to protein misfolding and harmful aggregate formation. Around 25% of our genes encode membrane proteins which are vital for cellular function. However, about 5-10% of these proteins mislocalise to the cytosol due to defects recognition or translocation.  Once mislocalised, the hydrophobic nature of membrane proteins makes them prone to aggregation, contributing to cellular dysfunction and diseases like Alzheimer's. Our laboratory focuses on unraveling the molecular mechanisms governing membrane protein proteostasis, spanning synthesis to integration into target membranes. With over 50% of drug targets being membrane proteins, our research not only addresses fundamental cellular processes but also holds promise for therapeutic interventions. Employing a multidisciplinary approach, we integrate proteomics, high-resolution imaging, bioinformatics, biochemistry, and structural biology methods to advance our understanding of membrane protein function and dynamics.

Qualifications

• PhD- Biochemistry and Molecular Biology
• MSc-Infection and Immunity
• BSc- Applied Biology and biochemistry
• Post graduate certificate in academic practise

Professional memberships

• Fellow of HEA
• Faculty member- H1 Connect
• Biochemical Society- Member
• UKRI panel member
• UKRI peer review college