Dr Jonathan Machin

Position: Postdoctoral researcher
Areas of expertise: Structural Biology; CryoEM; Bioinformatics; Membrane Proteins; Proteoliposomes; Machine Learning
Email: J.M.Machin@leeds.ac.uk
Website: Googlescholar | Researchgate | ORCID

Profile

Biochemisty (molecular and cellular) integrated Bachelors/Masters (MBiochem) from University of Oxford, UK (2015-2019)

Ph.D. in Biochemistry/Biophysics from Astbury Centre, University of Leeds (2019-2023)

Postdoctoral Researcher at Universtiy of Leeds (2023-present)

Research interests

My research interests focus on how membrane proteins fold, function, and interact within their unique lipid environments, particularly in the context of the diderm bacterial outer membrane and the constraints that imposes. Specifically, I explore the roles of protein-protein and protein-lipid interactions, membrane asymmetry and the dedicated assembly machinery on efficient folding of membrane proteins and assembly of complexes. In addition to standard biochemical and biophysical approaches, I exploit methods such as cryoEM, large-scale bioinformatic analysis (including machine learning) and the use of modern structural prediction and design tools to understand these questions.

<h4>Research projects</h4> <p>Some research projects I'm currently working on, or have worked on, will be listed below. Our list of all <a href="https://biologicalsciences.leeds.ac.uk/dir/research-projects">research projects</a> allows you to view and search the full list of projects in the faculty.</p>