Rational design and production of glyco-peptidic inhibitors of pathogens’ adhesion to host cells

Supervisor(s)

Dr Emanuele Paci

Dr Bruce Turnbull

Project description

The ability of protein molecules to stick to cells is crucial for life and disease. The project is based on a novel concept to design adhesive molecules based on multivalence and entropic stabilisation. The candidate will rationally design, produce and test flexible molecules linking sugars with peptides; linkers will be designed minimise entropy loss upon adhesion and maximise enthalpy gain through non-specific interactions with protein’s surface. The project will be carried out between Paci lab in the School of Molecular and Cellular Biology (rational design and simulation) and Turnbull lab in the School of Chemistry (production and assessment of glycopeptides). A strong physical background is an advantage, as well as programming and lab experience.

Key benefits

This studentship is funded by Leverhulme Trust for 3 years and can start anytime before the application deadline • Research Council Stipend • UK/EU Tuition Fees • Conference allowance • Research Costs

Entry requirements

Applicants should have/be expecting at least a 2.1 Hons. degree in a relevant subject. If English if not your first language you will be required to meet the university language requirements before registration https://www.leeds.ac.uk/info/123100/admissions/143/entry_requirements

How to apply

Please apply online

Please include supervisor name and project title.  A research proposal is not required.  Please upload a CV and transcripts.

How to apply (email)

fbsgrad@leeds.ac.uk

How to apply (phone)

+44 (0)113 343 8186