Functional Genomics in Sensory Neuroscience

Supervisor(s)

 Dr Viktor Lukacs

Prof Nikita Gamper

Project description

The Human Genome contains an estimated 20,000 protein-coding genes, a large portion of which encode products of unknown biological function. In the field of Sensory Neuroscience, for example, genes encoding receptors for mechanical pain, noxious cold, as well as several odorants and taste modalities have yet to be discovered. Identifying these molecules will open new chapters in our molecular-level understanding of the sensory nervous system, and provide targets for better therapy such as analgesics.

 We have established a novel experimental method to screening for and find such novel receptors. We combine state-of-the art techniques in molecular biology, imaging and Next-Gen Sequencing in a directed molecular evolution-based approach, using the genome itself as a screening library. Novel targets identified will be studied in collaboration with Prof. Nikita Gamper, involving in vivo and in vitro approaches to characterise the properties and physiological function of these genes. This exciting research will encompass the following methods:

 cell culture, molecular biology, mouse genetics, fluorescent microscopy and cell sorting, next-generation sequencing and bioinformatics analysis.

 A Ph.D position is now available in this newly launched laboratory, where the student will have access to first-hand tutelage and the newly-developed experimental techniques with a range of exciting new questions to choose from. The successful student must be self-motivated, a good communicator and have the ability to work collaboratively. The student will master and routinely use the techniques listed above to conduct research at the intersection of genomics and neuroscience, attend scientific conferences and produce high-impact publications. Experience in the methods listed above will be preferred but not strictly required.

Entry requirements

Candidates should have, or be expecting, a 2.1 hons at Undergraduate level or above, in a relevant subject. If English is not your first language, you will need a recognised English Language qualification to be admitted onto any of the University's degree programmes: language requirements https://www.leeds.ac.uk/info/123100/admissions/143/entry_requirements

How to apply

Please apply online

Select “PhD in Biological Sciences” as the proposed course

Please include supervisor name and project title.  A research proposal is not required.  Please upload a CV and transcripts.

How to apply (email)

fbsmera@leeds.ac.uk

How to apply (phone)

+44 (0)113 343 8186