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Dr Andrew Tuplin

  • Position: Associate Professor
  • Areas of expertise: Molecular Virology: Arboviruses: Flaviviruses (Dengue virus and Zika virus): Alphaviruses (Chikungunya virus): RNA biology: RNA structure, RNA binding proteins, ncRNA (lncRNA & circRNA):
  • Email: A.K.Tuplin@leeds.ac.uk
  • Phone: +44(0)113 343 5582
  • Location: 9.42 Garstang
  • Website: The Astbury Centre for Structural Molecular Biology

Profile

BSc (University of Edinburgh)

PhD (University of Edinburgh)
Research fellow, (CEH Oxford)
Research fellow, (University of Warwick)
Senior research fellow, (University of Warwick)

Responsibilities

  • Group Leader
  • SMCB Admissions Tutor
  • Program Lead: BiolSci and BioEnt

Research interests

Control of replication and translation in positive-strand RNA viruses:

Our research is focused on investigating how RNA viruses control replication and translation of their genomes through dynamic interactions between structured RNA, host-cell/viral proteins and different types of host-cell/viral non-coding RNA (e.g. siRNA, lncRNA and circRNA). Most of our work is focused on mosquito transmitted arboviruses such as chikungunya virus and dengue virus and the potential of such interactions as novel therapeutic targets.

As part of our research, we use a wide variety of cutting-edge molecular virology and cell biology approaches including genomics, proteomics, in cell RNA SHAPE-MaP and CryoEM approaches.

 

Our research is funded by the MRC, BBSRC and The Royal Society.

Group Members:

Dr Andrew Tuplin (PI)

Dr Sam Dobson (PDRA)

Molly Brereton (Research Technician)

Francesca Appadoo (PhD student)

Yuqian Liu (PhD student)

Zhaoxia Pang (PhD student)

Hind Almohammadi (PhD student)

Nora Alaamri (PhD student)

Lai Wei (PhD student)

<h4>Research projects</h4> <p>Some research projects I'm currently working on, or have worked on, will be listed below. Our list of all <a href="https://biologicalsciences.leeds.ac.uk/dir/research-projects">research projects</a> allows you to view and search the full list of projects in the faculty.</p>

Student education

Postgraduate Self-funded or Scholarship students:

I actively encourage and support applications from International self-funded or scholarship/fellowship PhD or MRes students. International students must have a good command of both written and spoken English. Applications can be made throughout the year.

Please email me directly for further information regarding PhD applications to the group. Further information, including international studentship fees and bench costs, can also be found at the following links:

Faculty of Biological Sciences: Graduate School

Project details on FindaPhD: Control and inhibition of virus replication

 

Postgraduate studentship areas in the Tuplin Group include:

  • Structure and interactions of dynamic RNA structure within virus genomes
  • Mechanistic analysis of RNA/protein interactions that control essential aspects of virus replication
  • Novel antiviral therapeutic targets
  • Structural and mechanistic analysis of host cell and viral ncRNA (siRNA, lncRNA & circRNA) during virus replication
  • RNA modification during virus replication

 

Research groups and institutes

  • Cell and Organismal Biology
  • Structural Biology
  • Microbiology
<h4>Postgraduate research opportunities</h4> <p>We welcome enquiries from motivated and qualified applicants from all around the world who are interested in PhD study. Our <a href="https://phd.leeds.ac.uk">research opportunities</a> allow you to search for projects and scholarships.</p>
Projects
    <li><a href="//phd.leeds.ac.uk/project/412-control-and-inhibition-of-virus-replication">Control and inhibition of virus replication</a></li>