Dr. William R. Critchley
- Position: Research Fellow
- Areas of expertise: endothelial cells; cell signalling; angiogenesis; immunity; flow cytometry
- Email: W.R.Critchley@leeds.ac.uk
- Location: 6.44 Garstang
- Website: ORCID
Obtained a first class degree in Human Biology and Infectious Diseases in 2010 from the University of Salford.
Spent 18 months as a research technician at the University of Manchester followed by an EPSRC-sponsored MRes in Translational Medicine: Interdisciplinary Molecular Medicine at the University of Manchester (distinction) in 2013.
Undertook a BBSRC-sponsored PhD in Immunology (supervised by Dr. James Fildes and Dr. Steven Shaw), awarded alongside the President's Doctoral Scholar Award from the University of Manchester in 2017. My PhD project involved the ex vivo perfusion of donor hearts prior to transplantation in order to evaluate the immunological load of the donor organ and how this could be manipulated to diminish the rejection response post-transplantation. This work involved significant collaboration with the pioneering surgical team of Prof Stig Steen at the University of Lund, where I spent several months over the course of my PhD.
I am interested in the post-translational modification of vascular endothelial growth factor receptor 2 and how this regulates angiogenesis.
I am investigating the attachment of ubiquitin and ubiquitin-related modifiers to the receptor and internalisation components in endothelial cells.<h4>Research projects</h4> <p>Any research projects I'm currently working on will be listed below. Our list of all <a href="https://biologicalsciences.leeds.ac.uk/dir/research-projects">research projects</a> allows you to view and search the full list of projects in the faculty.</p>
- First Class BSc Human Biology and Infectious Diseases (2010)
- MRes Translational Medicine: Interdisciplinary Molecular Medicine (distinction)
- PhD Immunology
- British Society for Cardiovascular Research