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Professor Alex Breeze

Professor Alex Breeze

  • Position: Professor of Biomolecular NMR
  • Areas of expertise: Biomolecular NMR; structural biology; biophysics; structure-based drug discovery; fragment-based lead discovery; mechanistic disease biology
  • Email: A.L.Breeze@leeds.ac.uk
  • Phone: +44(0)113 343 0087
  • Location: 10.28 LC Miall
  • Website: LinkedIn

Profile

BSc ARCS, PhD DIC, Imperial College London 1980-1987; SERC postdoctoral fellow, University of Oxford 1988-1991; College Lecturer, Corpus Christi College Oxford 1989-1992; Team Leader, BioNMR, AstraZeneca 1991-2001; Principal Scientist, BioNMR, AstraZeneca 2002-2014; Associate Director, Biophysics, AstraZeneca 2008-2011; Principal Scientist, Biophysics and Structural Chemistry, AstraZeneca 2011-2014; Professor of Biomolecular NMR, University of Leeds 2014-present.

Board member, MRC Molecular and Cellular Medicine Board (2019-). Member, Scientific Advisory Board, MRC UK Biomedical NMR Centre, Crick Institute (2017-). Previous board member, BBSRC Committee D and ALERT17.

Responsibilities

  • Director of NMR, Astbury Biostructure Laboratory
  • Director of Research Facilities and Infrastructure, Faculty of Biological Sciences

Research interests

We are interested in the structural molecular biology of disease processes, with a particular focus on NMR spectroscopy as a primary structural tool alongside other techniques including cryo-EM, X-ray crystallography and biophysical interaction analysis using e.g. SPR and ITC. Our biological and disease interests span signal transduction in oncology via fibroblast growth factor receptors and Ras pathway activation, through Ca2+ signalling in endothelial cells mediated by Rab-family GTPases, to infectious disease biology in the form of trypanosomatid translation initiation systems. We lever previous experience in the biopharma industry to identify novel therapeutic opportunities, including via fragment-based drug discovery.

<h4>Research projects</h4> <p>Some research projects I'm currently working on, or have worked on, will be listed below. Our list of all <a href="https://biologicalsciences.leeds.ac.uk/dir/research-projects">research projects</a> allows you to view and search the full list of projects in the faculty.</p>

Qualifications

  • BSc (Hons) ARCS Imperial College London
  • PhD DIC Imperial College London

Professional memberships

  • British Biophysical Society

Student education

See also:

Committees:

  • Member of Graduate School Committee (Faculty representative on Graduate Board Scholarships, Studentships and Prizes Group)

Research groups and institutes

  • Structural Biology
  • Cancer
<h4>Postgraduate research opportunities</h4> <p>We welcome enquiries from motivated and qualified applicants from all around the world who are interested in PhD study. Our <a href="https://phd.leeds.ac.uk">research opportunities</a> allow you to search for projects and scholarships.</p>
Projects
    <li><a href="//phd.leeds.ac.uk/project/1920-structural-and-mechanistic-studies-of-fibroblast-growth-factor-receptor-signalling">Structural and mechanistic studies of fibroblast growth factor receptor signalling</a></li>