Dr Sergei Krivov
- Position: RCUK Academic Research Fellow
- Areas of expertise: protein folding; molecular dynamics simulations; free energy landscape analysis; longitudinal big data analysis; biomarkers; reaction coordinates.
- Email: S.Krivov@leeds.ac.uk
- Phone: +44(0)113 343 3141
- Location: 10.132 Garstang
- Website: Astbury | Googlescholar | Researchgate
Quantitative analysis of complex biological dynamics.
Life manifests itself through complex dynamics across many scales, from wiggling and jiggling of atoms (protein folding) to transcription dynamics in gene regulatory networks, disease dynamics and population dynamics. Advances in experimental techniques resulted in availability of multidimensional, time-resolved data about dynamical processes. On the other hand, advances in computer hardware and simulation algorithms made it possible to obtain detailed dynamical picture of real-life biological processes on a computer. Computational experiments became a vital component of researches arsenal, as was highlighted by the recent Nobel prize awarded to three computational chemists. The large size of datasets generated by computer simulations or experiments makes the development of automated analysis tools very important, practically and conceptually. In our lab we focus on the development of an original state of the art approach which focuses specifically on accurate description of the dynamics and its application to the analysis of in-silico and in-vitro data.<h4>Research projects</h4> <p>Any research projects I'm currently working on will be listed below. Our list of all <a href="https://biologicalsciences.leeds.ac.uk/dir/research-projects">research projects</a> allows you to view and search the full list of projects in the faculty.</p>
- PhD Physics , Novosibirsk, Russia
- MS Physics of Non-Equilbrium Processes, Novosibirsk, Russia
Undergraduate project topics:
- Free energy landscape analysis of realistic protein folding simulations.
Research groups and institutes
- Structural Biology