Professor Elton Zeqiraj
- Position: Wellcome Trust Senior Fellow and Professor of Structural Biology
- Areas of expertise: Cell signaling structural biology; Ubiquitin; Early stage drug discovery
- Email: E.Zeqiraj@leeds.ac.uk
- Phone: +44(0)113 343 3079
- Location: 5.14 Roger Stevens
- Website: Lab website | PubMed | Googlescholar | ORCID
Research interests
Our lab studies how Ubiquitin governs cell signalling networks.
We are interested in ubiquitin structural biology with the main focus on deubiquitinating enzymes (a.k.a. DUBs). The majority of our efforts are dedicated to understanding how DUBs are activated allosterically, and how they can be inhibited when it is beneficial to do so.
Current major projects include:
- Understand DUB selectivity and physiological regulation
- Understand JAMM/MPN domain DUB allosteric activation
- Identification of JAMM/MPN domain DUB inhibitors
- Mass spectrometry infrastructure for in-cell structural biology
- Regulation of emergency Hematopoiesis by the Ubiquitin-proteasome system
- Regulation of immune signalling via ubiquitin-mediated receptor degradation
- State of the art electron detection for cyoEM at the Astbury Biostructure Laboratories
- Technology for high-throughput binding assays and screens
Qualifications
- Postdoctoral fellow, Mount Sinai Hospital, Toronto
- PhD in Structural Biology, University of Dundee, Dundee
- BSc (Hons) Biochemistry, University of Westminster, London
Professional memberships
- Member of the Biochemical Society