Professor Elton Zeqiraj

Research interests

Our lab studies how Ubiquitin governs cell signalling networks. 

We are interested in ubiquitin structural biology with the main focus on deubiquitinating enzymes (a.k.a. DUBs). The majority of our efforts are dedicated to understanding how DUBs are activated allosterically, and how they can be inhibited when it is beneficial to do so.

Current major projects include:

• Understand DUB selectivity and physiological regulation
• Understand JAMM/MPN domain DUB allosteric activation
• Identification of JAMM/MPN domain DUB inhibitors

<h4>Research projects</h4> <p>Any research projects I'm currently working on will be listed below. Our list of all <a href="https://biologicalsciences.leeds.ac.uk/dir/research-projects">research projects</a> allows you to view and search the full list of projects in the faculty.</p>

• Mass spectrometry infrastructure for in-cell structural biology
• Regulation of emergency Hematopoiesis by the Ubiquitin-proteasome system
• Regulation of immune signalling via ubiquitin-mediated receptor degradation
• State of the art electron detection for cyoEM at the Astbury Biostructure Laboratories

Qualifications

• Postdoctoral fellow, Mount Sinai Hospital, Toronto
• PhD in Structural Biology, University of Dundee, Dundee
• BSc (Hons) Biochemistry, University of Westminster, London

Professional memberships

• Member of the Biochemical Society

<h4>Postgraduate research opportunities</h4> <p>We welcome enquiries from motivated and qualified applicants from all around the world who are interested in PhD study. Our <a href="https://phd.leeds.ac.uk">research opportunities</a> allow you to search for projects and scholarships.</p>