Dr Scott Bowen
- Position: Lecturer in Exercise Physiology
- Email: T.S.Bowen@leeds.ac.uk
- Phone: +44(0)113 343 3834
- Location: 5.55q Garstang
My PhD studies were performed at the University of Leeds and helped better understand the cardiopulmonary and skeletal muscle limitations that occur during exercise in health and disease, particularly in heart failure patients. I was subsequently awarded a Postdoctoral Research Fellowship from the Alexander von Humboldt Foundation in Germany to support my postdoctoral studies at Leipzig Heart Center.
Together with Professor Volker Adams, we investigated the basic molecular mechanisms that act to induce skeletal muscle weakness in numerous chronic diseases while further developing therapeutic treatments. Further involvement in an EU FP7 funded grant in collaboration with colleagues at NTNU in Norway provided key findings on the efficacy of exercise training in heart failure, while participation in a Fondation Leducq Transatlantic Network of Excellence revealed modulation of sarcomeric signalosomes as therapy to combat muscle wasting. I returned to the School of Biomedical Sciences at the University of Leeds in 2017 as an independent investigator.
Mechanisms of muscle weakness and wasting.
Loss of muscle mass and strength occurs in many clinical conditions, and plays a critical role in pulmonary complications and disabilities observed in patients and leads to significant reductions in quality of life and survival. The aim of this laboratory is to identify key mechanisms contributing to muscle dysfunction in various diseases such as heart failure, and how this can be prevented through the development of novel therapies that include small-molecule inhibitors and exercise training. One particular area of interest is investigating why the main muscle of respiration, the diaphragm, becomes weak in acute and chronic disease.
Key research areas include:
- Molecular mediators of diaphragm weakness in heart failure
- Underlying mechanisms contributing to skeletal muscle loss in various clinical disorders
- Exercise training as a rescue intervention to prevent muscle impairments
- Development of novel small-molecule therapeutics to protect against muscle wasting
- Mechanisms underpinning exacerbated exercise intolerance in diabetic heart failure patients
- BSc (University of Leeds), MSc (Loughborough University), PhD (University of Leeds) 2008-2012, Postdoctoral Research Fellow (Heart Center Leipzig) 2013-2017