Dr Samit Chakrabarty

Dr Samit Chakrabarty

Profile

I am a systems neurophysiologist, studying plasticity and interaction between the spinal circuits and their modulators - the sensory inputs from periphery and descending inputs from brain.

PhD - University of Cambridge; Postdoc - Columbia University, NYC; Spinal Cord Research Centre, Winnipeg, Canada; Visiting Associate Professor - Panum Institute, University of Copenhagen; Research Associate Professor - Columbia University, NYC

Responsibilities

  • Translate Innovations Champion

Research interests

Interests https://www.researchgate.net/profile/Samit_Chakrabarty

Neurophysiology of Motor control Neuroscience

Neurophysiology and motor rehabilitaion http://www.fbs-wp.leeds.ac.uk/cpres/

Rehabilitation Robotics https://robotics.leeds.ac.uk/profiles/

Current projects:

  • Reflex reorganisation during development, post injury and ageing
  • Spinal cord injury and restoration of voluntary control
  • Development of smarter neuroprosthetics
  • Development of more efficient multichannel recording and stimulating devices
  • Systematic analysis of the neuronal architecture of the spinal cord and brain related to motor control
  • Application towards development of neuroprosthetics.

Techniques:

  • In-vivo electrophysiology - intracellular and extracellular recordings
  • Human neurophysiology and rehabilitation - Mobility disorders, sEMGs
  • Medical devices for imrpoved recording and stimulation
  • Tools to improve deliverly of drugs and modulation of the signal for implantables and wearables
  • Mathematical modelling
  • Immunohistochemistry

Motor action and role of spinal interneurones

A motor act is successful when an organism evades a predator, catches a prey, plays the violin or hurls insults. Motor action is only possible when the spinal motor effectors or motoneurones are active. To actively adjust their output depending on the need during a task, requires that these motoneurones are modulated, from moment to moment, either by feedback from the periphery or feedforward commands from the higher brain structures.

These regulatory inputs and their effect on the motoeneurones is what we study in my group, for both walking and reaching in humans and in animal models of developmental disorders and ageing. The ultimate goal is to decipher the underlying operating principles, which can then be used to better the therapies and interventions towards restoring motor control in people suffering from movement disorders.

Modulation of spinal motor output by inputs from brain and periphery

Examining the role of changing interactions between excitatory and inhibitory pospulatins of neurons within the spinal cord and its effects on segmental motor output.

Previously, we have shown that changing neuron counts and phenotypes in the spinal cord affects the motor output from the spinal segment during development. We are examining if this is true in disease states and ageing.

BIOMEDICAL RESEARCH exploring new diagnostic tools for neurologists and undertsanding neurological dysfunctions like Cerebral Palsy (http://www.fbs-wp.leeds.ac.uk/cpres/)

MATHEMATICAL MODELS OF BIOLOGICAL SYSTEMS. We are using the data generated from our biological experiments and developing a stochastic model. This allows to examine likely interactions between populations leading to changing motor outputs which are then verified experimentally.

APPLICATIONS. We work with Engineers to develop better smarter prosthetic devices and micro-electro-mechanical (MEMS) electrodes to facilitate recording and stimulation towards the same.

COLLABORATORS:

Our research is supported by the BBSRC, the International foundation for research in paraplegia, International Spinal Research Trust, Craig Nielsen Foundation and The Royal Society.

I am a Innovation Champion as part of the Univeristy's partnership with Translate:, on-hand to offer advice about technology progression and enhance innovation skills and capabilities - http://www.translate-medtech.ac.uk/translate-me/innovation-champions/

<h4>Research projects</h4> <p>Any research projects I'm currently working on will be listed below. Our list of all <a href="https://biologicalsciences.leeds.ac.uk/dir/research-projects">research projects</a> allows you to view and search the full list of projects in the faculty.</p>

Qualifications

  • PhD (Cantab)

Student education

Undergraduate project topics:

Systematic analysis of the neuronal architecture of the spinal cord and brain related to motor control, application towards development of neuroprosthetics. Techniques: Systems neurophysiology, Immunohistochemistry, Mathematical modelling

Postgraduate studentship areas:

  • Reflex reorganisation during development, post injury and ageing
  • Spinal cord injury and restoration of voluntary control
  • Development of smarter neuroprosthetics
  • Development of more efficient multichannel recording and stimulating devices

See also:

Research groups and institutes

  • Neuroscience
  • Sport and Exercise Sciences

Current postgraduate research students

<h4>Postgraduate research opportunities</h4> <p>We welcome enquiries from motivated and qualified applicants from all around the world who are interested in PhD study. Our <a href="https://biologicalsciences.leeds.ac.uk/research-opportunities">research opportunities</a> allow you to search for projects and scholarships.</p>