Professor John Colyer

Profile

We are interested in the control of cardiac muscle behaviour by physiological and pathological stresses. These stresses control cardiac function by post-translational modification of key proteins (phosphorylation, oxidation, etc.) in Excitation-Contraction Coupling, and we develop new tools to define the role of these site-specific modifications in physiological and pathological circumstances. We collaborate with clinicians and technologists to perform medically directed molecular studies (super-resolution microscopy, biomarker detection, quantitative bioscience).

Our research has direct application to industry, and we collaborate with companies – most notably Badrilla, a spin-out company from this laboratory to produce new experimental tools for the cardiovascular field, and to develop quantitative biomarker detection approaches for systems biology. We collaborate with clinicians to develop improved diagnostic tests for critical diseases, notably acute kidney injury.

BSc; CNAA; MPhil, London. PhD, Southampton. Post-doctoral work in the MRC Group in Signal Transduction, University of Calgary, Canada. British Heart Foundation Lecturer at University of Leeds, 1991-99. Senior Lecturer, 1999-current. Founder of Fluoroscience Ltd (biotech/drug discovery company), 1998. This role continues to exceed that of an established programme. We are charged with building a consortium of companies to host placements as well as actively promote the new course to candidates. Furthermore, I am involved in extensive admissions and interviewing - on behalf of a consortia of UK companies. In addition, I have to manage many non-academic teaching staff, and to serve a strategic steering group comprising the partners. From this year onwards, I will also need to establish and serve an alumni body (of graduated students) so that the University and FBS can benefit from this professional group in the medium/long term.

Responsibilities

  • Programme Leader MSc Biopharmaceutical Development

Research interests

Natural & Therapeutic Control of Cardiac Function

Acute Kidney Injury (with Dr Andrew Lewington, St. James Hospital, Leeds)

Quantitative western blotting (with Badrilla Ltd. https://badrilla.com/technology/)

<h4>Research projects</h4> <p>Any research projects I'm currently working on will be listed below. Our list of all <a href="https://biologicalsciences.leeds.ac.uk/dir/research-projects">research projects</a> allows you to view and search the full list of projects in the faculty.</p>

Qualifications

  • BSc, CNAA; MPhil, London; PhD 1988, Southampton

Professional memberships

  • Biochemical Society (Ambassador)

Student education

Oxidation of CaMKII in Health & DiseaseOxidation of CaMKII in Health & Disease
Keywords: peptide chemistry, mass spectrometry, immunoassay. (Laboratory) Protein phosphorylation in cardiac muscle contraction
Keywords: Signal transduction, cardiac myocytes, immunotechniques (blotting/microscopy), microinjection (Laboratory) Control of cellular differentiation: Cellular transplantation therapies
Keywords: In title (Literature){"BIOL5269M":"Commercialising Biopharmaceutical Products","BIOL5280M":"Integrated Drug Development Plan","BMSC2120":"Scientific Skills"}{"BIOL2210\/BIOC2301":"Integrated Biochemistry\/Biological Membranes","BIOL5180M":"Biopharmaceutical Drug Discovery and Pre-clinical testing","BIOL5269M":"Commercialising Biopharmaceutical Products","BIOL5280M":"Integrated Drug Development Plan","BIOL5294M":"MSc Bioscience Research Project Proposal","BIOL5371M":"Research Planning and Scientific Communication","BIOL5392M":"Bioscience MSc Research Project","BIOL5397M":"Practical Skills for a Regulatory Environment","BMSC1103":"Basic Laboratory and Scientific Skills","BMSC1213":"Basic Laboratory and Scientific Skills 2","BMSC2120":"Scientific Skills","BMSC3101":"Inherited Disorders","BMSC3301":"Research Project in Biomedical Sciences"}


Studentship information

Undergraduate project topics:

  • Oxidation of CaMKII in Health & Disease
    Keywords: peptide chemistry, mass spectrometry, immunoassay. (Laboratory)
  • Protein phosphorylation in cardiac muscle contraction
    Keywords: Signal transduction, cardiac myocytes, immunotechniques (blotting/microscopy), microinjection (Laboratory)
  • Control of cellular differentiation: Cellular transplantation therapies
    Keywords: In title (Literature)

Postgraduate studentship areas:

  • Oxidation of CaMKII in Health & Disease
  • Quantitative detection of diagnostic biomarkers
  • Definition of the molecular basis of cardiovascular disease

See also:

Modules managed

BIOL5269M - Commercialising Biopharmaceutical Products
BIOL5280M - Integrated Drug Development Plan
BMSC2120 - Scientific Skills

Modules taught

BIOL2210/BIOC2301 - Integrated Biochemistry/Biological Membranes
BIOL5180M - Biopharmaceutical Drug Discovery and Pre-clinical testing
BIOL5269M - Commercialising Biopharmaceutical Products
BIOL5280M - Integrated Drug Development Plan
BIOL5294M - MSc Bioscience Research Project Proposal
BIOL5371M - Research Planning and Scientific Communication
BIOL5392M - Bioscience MSc Research Project
BIOL5397M - Practical Skills for a Regulatory Environment
BMSC1103 - Basic Laboratory and Scientific Skills
BMSC1213 - Basic Laboratory and Scientific Skills 2
BMSC2120 - Scientific Skills
BMSC3101 - Inherited Disorders
BMSC3301 - Research Project in Biomedical Sciences

Academic roles

PGT Programme Leader - MSc Biopharmaceutical Development This role continues to exceed that of an established programme. We are charged with building a consortium of companies to host placements as well as actively promote the new course to candidates. Furthermore, I am involved in extensive admissions and interviewing - on behalf of a consortia of UK companies. In addition, I have to manage many non-academic teaching staff, and to serve a strategic steering group comprising the partners. From this year onwards, I will also need to establish and serve an alumni body (of graduated students) so that the University and FBS can benefit from this professional group in the medium/long term

Committees

Member of Masters Taught Student Education Committee

Current postgraduate research students

<h4>Postgraduate research opportunities</h4> <p>We welcome enquiries from motivated and qualified applicants from all around the world who are interested in PhD study. Our <a href="https://biologicalsciences.leeds.ac.uk/research-opportunities">research opportunities</a> allow you to search for projects and scholarships.</p>