Protein structure, stability and dynamics
Our purpose
Our aim is to generate new knowledge that will deliver societal benefits in areas including cancer, antimicrobial resistance, neurodegenerative disease, biotechnology, virology, and microbiology.
Proteins are complex, dynamic, three-dimensional molecules which play critical roles in biology.
Understanding their structure and function – and what happens when they abnormally change -is essential for preventing and developing new treatments for diseases.
Our research focuses on understanding the structure of proteins and how they assemble, their interactions with drug molecules, and how changes in their structure cause disease.
Working with business
The KTP has created a foundation of knowledge that will provide huge long-term benefits.
Through a Knowledge Transfer Partnership, we helped Spur Therapeutics move closer to their goal of creating a vector that will allow them to treat a wider range of illnesses using gene therapy.
Facilities
Our world-class facilities enable us to analyse protein structure and function in exquisite detail.
Biomolecular Mass Spectrometry
A cutting edge facility which enables the investigation of the mass, structure and conformation of biomolecules and their complexes.
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Nuclear Magnetic Resonance
Pioneering technology which can analyse molecules and chemical reactions.
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Electron Microscopy
Electron Microscopy generates high resolution data to produce structures of a broad range of complexes, such as membrane proteins, ribosomes and viruses.
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Biomolecular Interactions
A facility which provides molecular analysis of a very wide range of molecules.
MoreInterdisciplinary networks
We collaborate with researchers and industry across biology, chemistry, physics and medicine, using our expertise to drive forward innovative solutions at pace and scale.
The Astbury Centre for Structural Molecular Biology
The Centre has outstanding expertise and research infrastructure in chemical biology, biophysics and all of the major techniques in structural molecular biology.
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