Antibodies are the best-studied group of protein binding molecules to date, and have been successfully applied to a variety of biological and medical problems.
They are particularly useful as research reagents but in some applications their size and complexity can be limiting, there can be batch-to-batch variability and in some cases poor validation.
Alternative small, robust, easily manipulated non-antibody scaffolds provide a complementary technology for many molecular recognition solutions.
Reagents based on the Affimer scaffold can be selected to bind to, and block specific surfaces on target proteins and therefore have potential as molecular biology tools and therapeutic agents.
As diagnostic tools they can be used for the detection and imaging of proteins in patient samples. The BSTG will screen for Affimer proteins that bind to your target molecules by using phage display.
Development of Affimers - Phage display
Phage display is a well established, robust and reliable in vitro selection method, that is ideal for the generation of affinity reagents.
We have generated two highly complex phage display libraries each containing more than 10 billion Affimer proteins.
We have generated Affimer proteins to more than 500 target proteins, peptides and small molecules.