Tyrosine Kinases

Tyrosine kinases

Bunney, T.D., Inglis, A.J., Sanfelice, D., Farrell, B., Kerr, C.J., Thompson, G.S., Masson, G., Thivagarajan, N., Svergun, D.I., Williams, R.L., Breeze, A.L. & Katan, M., Disease variants of FGFR3 reveal molecular basis for the recognition and additional roles for Cdc37 in Hsp90 chaperone system., Structure, 26, 446-458, 2018.

Sanfelice, D., Koss, H., Bunney, T.D., Thompson, G.S., Farrell, B., Katan, M. & Breeze, A.L., NMR backbone assignments of the tyrosine kinase domain of human fibroblast growth factor receptor 3 in apo state and in complex with inhibitor PD173074., Biomolecular NMR Assignments, Mar 26, doi: 10.1007/s12104-018-9814-7, 2018.

Patani, H., Bunney, T.D., Thiyagaran, N., Norman, R.A., Ogg, D., Breed, J., Ashford, P., Potterton, A., Edwards, M., Williams, S.V., Thompson, G.S., Pang, C.S.M., Knowles, M.A., Breeze, A.L., Orengo, C., Phillips, C. & Katan, M., Landscape of activating cancer mutations in FGFR kinases and their differential responses to inhibitors in clinical use., Oncotarget, 7, 24252-24268, 2016.

Klein, T., Vajpai, N., Phillips, J.J., Davies, G., Holdgate, G.A., Phillips, C., Tucker, J.A., Norman, R.A., Scott, A.D., Higazi, D.R., Lowe, D., Thompson, G.S. & Breeze, A.L., Structural and dynamic insights into the energetics of activation loop rearrangement in FGFR1 kinase., Nature Communications, 6, 7877, doi: 10.1038/ncomms8877, 2015.

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