Protein-protein and protein-ligand interactions

Grison, C.M., Miles, J.A., Robin, S., Wilson, A.J. & Aitken, D.J., An alpha-helix-mimicking 12,13-helix: Designed a/b/g-foldamers as selective inhibitors of protein-protein interactions., Angewandte Chemie International Edition, 55, 11096-11100, 2016.

Barnard A., Long, K., Martin, H.L., Miles, J.A., Edwards, T.A. Tomlinson, D.C., Macdonald A. & Wilson, A.J., Selective and potent proteomimetic inhibitors of intracellular protein-protein interactions., Angewandte Chemie-International Ediition, 54, 2960-2965, 2015.

Fisher, M., Basak, R., Kalverda, A.P., Fishwick C.W.G., Turnbull, W.B. & Nelson, A., Discovery of novel FabF ligands inspired by platensimycin by integrating structure based design with diversity-oriented synthetic accessibility, Organic & Biomolecular Chemistry, 12, 486-494, 2014.

Foster, T.L., Thompson, G.S., Kalverda, A.P., Kankanala, J., Bentham, M., Wetherill, L.F., Thompson, J., Barker, A.M., Clarke, D., Noerenberg, M., Pearson, A.R., Rowlands, D.J., Homans, S.W., Harris, M., Foster, R. & Griffin, S.D.C., Structure-guided design affirms inhibitors of Hepatitis C virus p7 as a viable class of antivirals targeting virion release., Hepatology 59, 408-422, 2014.

Syme, N.R., Dennis, C., Bronowska, A., Paesen, G.C. & Homans, S.W., Comparison of entropic contributions to binding in a “hydrophilic” versus “hydrophobic” ligand-protein interaction., Journal of the American Chemical Society, 132, 8682-8689, 2010.

Stöckmann, H., Bronowska, A., Syme, N.R., Thompson, G.S., Kalverda, A.P., Warriner, S.L. & Homans, S.W., Residual ligand entropy in the binding of p-substituted benzenesolfonamide ligands to bovine carbonic anhydrase II, Journal of the American Chemical Society, 130, 12420-12426, 2008.

Homans, S.W., Dynamics and thermodynamics of ligand-protein interactions, Topics in Current Chemistry, 272, 51-82, 2007.

MacRaild, C.A., Daranas, A.H., Bronowska, A. & Homans, S.W., Global changes in local protein dynamics reduce the entropic cost of carbohydrate binding in the arabinose-binding protein, Journal of Molecular Biology, 368, 822-832, 2007.

Homans, S.W., Water, water everywhere – except where it matters, Drug Discovery Today, 12, 534-539, 2007.

Syme, N.R., Dennis, C., Phillips, S.E.V. & Homans, S.W., Origin of heat capacity changes in a “Nonclassical” hydrophobic interaction, Chembiochem, 8, 1509-1511, 2007.

Barratt, E., Bingham, R.J., Warner, D.J., Laughton, C.A., Phillips, S.E.V. & Homans, S.W., Van der waals interactions dominate ligand-protein association in a protein binding site occluded from solvent water, Journal of the American Chemical Society, 127, 11827-11834, 2005.

Homans, S.W., Probing the binding entropy of ligand-protein interactions by NMR, Chembiochem, 6, 1585-1591, 2005.

Bingham, R., Bodenhausen, G., Findlay, J.B.C., Hsieh, S., Kalverda, A.P., Perazzalo, C., Phillips, S.E.V., Seshadri, K., Turnbull, W.B. & Homans, S.W., Thermodynamics of binding 2-methoxy-3-isopropylpyrazine and 2-methoxy-3-isobutylpyrazine to the Major Urinary Protein, Journal of the American Chemical Society, 126, 1675-1681, 2004.

Homans, S.W., NMR spectroscopy tools for structure-aided drug design, Angewandte Chemie, 43, 290-300, 2004.

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