Applications

2013

Edwards, T., Pearson, A., Thompson, G.S., Kalverda, A.P., Farrance, O., Brockwell, D. & Morgan G., Tools and Techniques in Biomolecular Science, (Divan, A. & Royds, J. eds.), Structural analysis of proteins: X-ray crystallography, NMR, AFM and CD spectroscopy, pp 261-294, Oxford, UK, Oxford University Press, 2013.

2012

Cox G., Thompson, G.S., Jenkins, H.T., Peske, F., Savelsbergh, A., Rodnina, M.V., Wintermeyer, W., Homans, S.W., Edwards, T.A. & O’Neill, A.J., Ribosome clearance by FusB-type proteins mediates resistance to the antibiotic fusidic acid,  Proceedings of the National Academy of Sciences of the United States of America, 109, 2102-2107, 2012.

Pashley, C.L., Morgan, G.J., Kalverda, A.P., Thompson, G.S., Kleanthous, C. & Radford, S.E., Conformational properties of the unfolded state of Im7 in nondenaturing conditions, Journal of Molecular Biology, 416, 300-318, 2012.

Czaljick, A., Thompson, G.S., Khan, G.N., Kalverda, A.P., Homans, S.W. & Trinick, J., H-1, N-15 and C-13 backbone chemical shift assignment of the titin A67-A68 domain tandem, Biomolecular NMR Assignments, 6, 39-41, 2012.

2011

Eichner, T., Kalverda, A.P., Thompson, G.S., Homans, S.W. & Radford, S.E., Conformational conversion during amyloid formation at atomic resolution, Molecular Cell, 41, 161-172, 2011.

Heyda, J., Kozisek, M., Bednarova, L., Thompson, G.S., Konvalinka, J., Vondrasek, J. & Jungwirth, P., Urea and Guanidinium induced denaturation of a Trp-cage miniprotein., Journal of Physical Chemistry B, 115, 8910-8924, 2011.

Woods, L.A., Platt, G.W., Hellewel, A.L., Hewitt, E.W., Homans, S.W., Ashcroft, A.E. & Radford, S.E., Ligand binding to distinct states diverts aggregation of an amyloid forming protein., Nature Chemical Biology, 7, 730-739, 2011.

Eichner, T. & Radford, S.E., Understanding the complex mechanisms of beta(2)-microglobulin amyloid assembly, FEBS Journal, 278, 3868-3883, 2011.

2010

Syme, N.R., Dennis, C., Bronowska, A., Paesen, G.C. & Homans, S.W., Comparison of entropic contributions to binding in a “hydrophilic” versus “hydrophobic” ligand-protein interaction., Journal of the American Chemical Society, 132, 8682-8689, 2010.

Houssen, W.E., Wright, S.H., Kalverda, A.P., Thompson, G.S., Kelly, S.M. & Jaspars, M., Solution structure of the leader sequence of the Patellamide precursor peptide, PatE1-34, Chembiochem, 11, 1867-1873, 2010.

Campbell F., PLante, J.P., Edwards, T.A., Warriner, S.L. & Wilson, A.J., N-alkylated oligoamide alpha-helical proteomimetics, Organic & Biomolecular Chemistry, 8, 2344-2351, 2010.

2009

Platt, G.W., Xue, W.F., Homans, S.W. & Radford, S.E., Probing dynamics within amyloid fibrils using a novel capping method., Angewandte Chemie-International Edition, 48, 5705-5707, 2009.

Kalverda A.P., Thompson, G.S., Vogel, A., Schröder, M., Bowie, A.G., Khan, A.R. & Homans, S.W., Poxvirus K7 protein adopts a Bcl-2 fold: Biochemical mapping of its interactions with human DEAD box RNA Helicase DDX3, Journal of Molecular Biology, 385, 843-853, 2009.

Routledge, K.E., Tartaglia, G.G., Platt, G.W., Vendruscolo, M. & Radford, S.E., Competition between intramolecular and intermolecular interactions in an amyloid forming protein., Journal of Molecular Biology, 389, 776-786, 2009.

2008

Stöckmann, H., Bronowska, A., Syme, N.R., Thompson, G.S., Kalverda, A.P., Warriner, S.L. & Homans, S.W., Residual ligand entropy in the binding of p-substituted benzenesolfonamide ligands to bovine carbonic anhydrase II, Journal of the American Chemical Society, 130, 12420-12426, 2008.

Platt, G.W., Routledge, K.E., Homans, S.W. & Radford, S.E., Fibril growth kinetics reveal a region of beta(2)-microglobulin important for nucleation and elongation of aggregation., Journal of Molecular Biology, 378, 251-263, 2008.

Rolfsson, O., Toropova, K., Morton, V., Francese, S., Basnak, G., Thompson, G.S., Homans, S.W., Ashcroft, A.E., Stonehouse, N.J., Ranson, N.A. & Stockley, P.G., RNA packing specificity and folding during assembly of the bacteriophage MS2., Computational and Mathematical Methods in Medicine, 9, 339-349, 2008.

Pellecchia, M., Bertini, I., Cowburn, D., Dalvit, C., Giralt, E., Jahnke, W., James, T.L., Homans, S.W., Kessler, H., Luchinat, C., Meyer, B., Oschkinat, H., Peng, J., Schwalbe, H., & Siegal, G., Perspectives on NMR in drug discovery: a technique comes of age., Nature Reviews Drug Discovery, 7, 738-745, 2008.

2007

Whittaker, S.B.M., Spence, G.R., Grossmann, J.G., Radford, S.E. & Moore, G.R., NMR analysis of the conformational properties of the trapped on-pathway folding intermediate of the bacterial immunity protein Im7, Journal of Molecular Biology, 366, 1001-1015, 2007.

Homans, S.W., Dynamics and thermodynamics of ligand-protein interactions, Topics in Current Chemistry, 272, 51-82, 2007.

Perazzolo, C., Verde, M., Homans, S.W. & Bodenhausen, G., Evidence of chemical exchange in recombinant Major Urinary Protein and quenching thereof upon pheromone binding, Journal of Biomolecular NMR, 38, 3-9, 2007.

MacRaild, C.A., Daranas, A.H., Bronowska, A. & Homans, S.W., Global changes in local protein dynamics reduce the entropic cost of carbohydrate binding in the arabinose-binding protein, Journal of Molecular Biology, 368, 822-832, 2007.

Homans, S.W., Water, water everywhere – except where it matters, Drug Discovery Today, 12, 534-539, 2007.

Syme, N.R., Dennis, C., Phillips, S.E.V. & Homans, S.W., Origin of heat capacity changes in a “Nonclassical” hydrophobic interaction, Chembiochem, 8, 1509-1511, 2007.

Burnley, B.T., Kalverda, A.P., Paisey, S.J., Berry, A. & Homans, S.W., Hadamard NMR spectroscopy for relaxation measurements of large (>35 kDa) proteins, Journal of Biomolecular NMR, 39, 239-245, 2007.

Stockley, P.G., Rolfsson, O., Thompson, G.S., Basnak, G., Francese, S., Stonehouse, N.J., Homans, S.W. & Ashcroft, A.E., A simple, RNA-mediated allosteric switch controls the pathway to formation of a T=3 viral capsid, Journal of Molecular Biology, 369, 541-552, 2007.

2006

Gspooner, J., Hopearuoho, H., Whittaker, S.B.M., Spence, G.R., Moore, G.R., Paci, E., Radford, S.E. & Vendruscolo, M., Determination of an ensemble of structures representing the intermediate state of the bacterial immunity protein Im7, Proceedings of the National Academy of Sciences of the United States of America, 103, 99-104, 2006.

Jahn, T.R., Parker, M.J., Homans, S.W. & Radford, S.E., Amyloid formation under physiological conditions proceeds via a native-like folding intermediate, Nature Structural & Molecular Biology, 13, 195-201, 2006.

2005

Knight, P.J., Thirumurugan, K., Xu, Y., Wang, F., Kalverda, A.P., Stafford III, W.F., Sellers, J.R. & Peckham, M. The predicted coiled-coil domain of Myosin 10 forms a novel elongated domain that lengthens the head, Journal of Biological Chemistry, 280, 34702-34708, 2005.

Barratt, E., Bingham, R.J., Warner, D.J., Laughton, C.A., Phillips, S.E.V. & Homans, S.W., Van der waals interactions dominate ligand-protein association in a protein binding site occluded from solvent water, Journal of the American Chemical Society, 127, 11827-11834, 2005.

Homans, S.W., Probing the binding entropy of ligand-protein interactions by NMR, Chembiochem, 6, 1585-1591, 2005.

Platt, G.W., McParland, V.J., Kalverda, A.P., Homans, S.W. & Radford, S.E., Dynamics in the unfolded state of beta(2)-microglobulin studied by NMR, Journal of Molecular Biology, 346, 279-294, 2005.

Kalverda, A.P., Thompson, G.S. & Turnbull, W.B., The importance of protein structural dynamics and the contribution of NMR spectroscopy, Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics, 6,  2578-2582, 2005.

2004

Bingham, R., Bodenhausen, G., Findlay, J.B.C., Hsieh, S., Kalverda, A.P., Perazzalo, C., Phillips, S.E.V., Seshadri, K., Turnbull, W.B. & Homans, S.W., Thermodynamics of binding 2-methoxy-3-isopropylpyrazine and 2-methoxy-3-isobutylpyrazine to the Major Urinary Protein, Journal of the American Chemical Society, 126, 1675-1681, 2004.

Turnbull, W.B., Shimizu, K.H., Chatterjee, D., Homans, S.W. & Treumann, A., Identification of the 5-methylthiopentosyl substituent in mycobacterium tuberculosis lipoarabinomannan, Angewandte Chemie, 43, 3918-3922, 2004.

Homans, S.W., NMR spectroscopy tools for structure-aided drug design, Angewandte Chemie, 43, 290-300, 2004.

Spence, G.R., Capaldi, A.P. & Radford, S.E., Trapping the on-pathway folding intermediate of Im7 at equilibrium, Journal of Molecular Biology, 341, 215-226, 2004.

Gorski, S.A., Le Duff, C.S., Capaldi, A.P., Kalverda, A.P., Beddard, G.S., Moore, G.R. & Radford S.E., Equilibrium hydrogen exchange reveals extensive hydrogen bonded secondary structure in the on-pathway intermediate of Im7, Journal of Molecular Biology, 337, 183-193, 2004.

Hernández-Daranas, A., Kalverda, A.P., Chiovitti, A. & Homans, S.W., Backbone resonance assignment of the L-arabinose binding protein in complex with D-galactose, Journal of Biomolecular NMR, 28, 191-192, 2004.

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