Applications

2018

Knight, P.D., Karamanos, T.K., Radford, S.E. & Ashcroft, A.E., Identification of a novel site of interaction between ataxin-3 and the amyloid aggregation inhibitor polyglutamine binding protein., European Journal of Mass Spectrometry, 24, 129-140, 2018.

Bunney, T.D., Inglis, A.J., Sanfelice, D., Farrell, B., Kerr, C.J., Thompson, G.S., Masson, G., Thivagarajan, N., Svergun, D.I., Williams, R.L., Breeze, A.L. & Katan, M., Disease variants of FGFR3 reveal molecular basis for the recognition and additional roles for Cdc37 in Hsp90 chaperone system., Structure, 26, 446-458, 2018.

Gatta, A.T., Sauerwein, A.C., Zhuravleva, A., Levine, T.P. & Matthews, S., Structural insights into a START-like domain in Lam4 and its interaction with sterol ligands., Biochemical and Biophysical Research Communications, 495, 2270-2274, 2018.

Sanfelice, D., Koss, H., Bunney, T.D., Thompson, G.S., Farrell, B., Katan, M. & Breeze, A.L., NMR backbone assignments of the tyrosine kinase domain of human fibroblast growth factor receptor 3 in apo state and in complex with inhibitor PD173074., Biomolecular NMR Assignments, Mar 26, doi: 10.1007/s12104-018-9814-7, 2018.

Texeira, J.M.C., Skinner, S.P., Arbesu, M., Breeze, A.L. & Pons, M., Farseer-NMR: automatic treatment, analysis and plotting of large, multi-variable NMR data., Journal of Biomolecular NMR, https://doi.org/10.1007/s10858-018-0182-5, 2018.

Doherty, C.P.A., Young, L.M., Karamanos, T.K., Smith, H.I., Jackson, M.P., Radford, S.E. & Brockwell, D.J., A peptide-display protein scaffold to facilitate single molecule force studies of aggregation-prone peptides., Protein Science, 27, 1205-1217, 2018.

Martin, E.M., Jackson, M.P., Gamerdinger, M., Gense, K., Humes, J.R., Karamanos, T.K., Deureling, E., Ashcroft, A.E. & Radfrod, S.E., Conformational flexibility within the nascent polypeptide associated complexes enables interactions with structurally diverse client proteins., Journal of Biological Chemistry, 293, 8554-8568, 2018.

2017

Hewitt, S.H., Filby M.H., Hayes, E., Kuhn, L.T., Kalverda, A.P., Webb, M. & Wilson, A.J., Protein surface mimetics; understanding how ruthenium tris(bipyridines) interact with proteins, ChemBioChem, 18, 223-231, 2017.

Zhuravleva A. & Korzhnev, D.M., Protein folding by NMR, Progress in Nuclear Magnetic Resonance Spectroscopy, 100, 52-77, 2017.

Schnieders, R., Richter, C., Warhaut, S., de Jesus, V., Keyhani, S., Duchardt-Ferner, E., Keller, H., Wohnert, J., Kuhn, L.T., Breeze, A.L., Bermel, W., Schwalbe, H. & Furtig, B., Evaluation of 15N-detected H-N correlation experiments on increasingly large RNAs., Journal of Biomolecular NMR, DOI 10.1007/s10858-017-0132-7, 2017.

Wieteska L., Shahidi, S. & Zhuravleva, A., Allosteric fine-tuning of the conformational equilibrium poises the chaperone BiP for post-translational regulation., ELIFE, 6, e29430, 2017.

2016

Hiruma-Shimizu, K., Shimizu, H., Thompson, G.S., Kalverda, A.P. & Patching, S.G., Deuterated detergents for structural and functional studies of membrane proteins: properties, chemical synthesis and applications., Molecular Membrane Biology, doi: 10.3109/09687688.2015.1125536,  2016. 

Tomlinson, J.H., Thompson, G.S., Kalverda, A.P., Zhuravleva, A., Homans, S.W.  & O’Neill, A., A target protection mechanism of antibiotic resistance at atomic resolution: insights into FusB-type fusidic acid resistance, Scientific Reports 6, Article number: 19524, doi: 10.1038/srep19524, 2016.

Pashley, C.L., Hewitt, E.W. & Radford, S.E., Comparison of the aggregation of homologous b2-microglobulin variants reveals protein solubility as a key determinant of amyloid formation., Journal of Molecular Biology, 428, 631-643, 2016.

Karamanos, T., Pashley, C.P., Kalverda, A.P., Thompson, G.S., Mayzel, M., Orekhov, V.Y. & Radford, S.E., A population shift between sparsely-populated folding intermediates determines amyloidogenicity., Journal of the American Chemical Society, 138, 6271-6280, 2016.

Patani, H., Bunney, T.D., Thiyagaran, N., Norman, R.A., Ogg, D., Breed, J., Ashford, P., Potterton, A., Edwards, M., Williams, S.V., Thompson, G.S., Pang, C.S.M., Knowles, M.A., Breeze, A.L., Orengo, C., Phillips, C. & Katan, M., Landscape of activating cancer mutations in FGFR kinases and their differential responses to inhibitors in clinical use., Oncotarget, 7, 24252-24268, 2016.

Grison, C.M., Miles, J.A., Robin, S., Wilson, A.J. & Aitken, D.J., An alpha-helix-mimicking 12,13-helix: Designed a/b/g-foldamers as selective inhibitors of protein-protein interactions., Angewandte Chemie International Edition, 55, 11096-11100, 2016.

2015

Azzarito, V., Miles, J.A., Fisher, J., Edwards, T.A., Warriner, S.L. & Wilson, A.J., Stereocontrolled protein surface recognition using chiral oligoamide proteomimetic foldamers., Chemical Science, 6, 2434-2443, 2015.

Barnard A., Long, K., Martin, H.L., Miles, J.A., Edwards, T.A. Tomlinson, D.C., Macdonald A. & Wilson, A.J., Selective and potent proteomimetic inhibitors of intracellular protein-protein interactions., Angewandte Chemie-International Ediition, 54, 2960-2965, 2015.

Evans K., Bhamra, I., Wheelhouse, R.T., Arnold, J.R.P. & Fisher, J., Stabilization of a bimolecular triplex by 3’-S-Phosphorothiolate modifications: An NMR and UV thermal melting investigation., Chemistry-A European Journal, 21, 7278-7284, 2015.

Monteiro, D.C.F., Patel, V., Bartlett, C.P., Nozaki, S., Grabt, T.D., Gowdy, J.A., Thompson, G.S., Kalverda, A.P., Snell, E.H., Niki, H., Pearson, A,R. & Webb, M.E., The structure of the PanD/PanZ protein complex reveals negative feedback regulation of pantothenate biosynthesis by coenzyme A., Chemistry & Biology, 22, 492-503, 2015.

Tipping, K.W., Karamanos, T.K., Jakhria, T., Ladanza, M.G., Goodchild, S.C., Tuma, R., Ranson, N.A., Hewitt, E.W. & Radford, S.E., pH induced molecular shedding drives the formation of amyloid fibril derived oligomers., Proceedings of the National Academy of Sciences of the United States of America, 112, 5691-5696, 2015.

Klein, T., Vajpai, N., Phillips, J.J., Davies, G., Holdgate, G.A., Phillips, C., Tucker, J.A., Norman, R.A., Scott, A.D., Higazi, D.R., Lowe, D., Thompson, G.S. & Breeze, A.L., Structural and dynamic insights into the energetics of activation loop rearrangement in FGFR1 kinase., Nature Communications, 6, 7877, doi: 10.1038/ncomms8877, 2015.

Zhuravleva, A. & Gierasch, L.M., Substrate-binding domain conformational dynamcis mediate Hsp70 allostery., Proceedings of the National Academy of Sciences of the United States of America, 112, E2865-E2873, 2015.

Karamanos, T.K, Kalverda, A.P. Thompson, G.S. & Radford, S.E., Mechanisms of amyloid formation revealed by solution NMR., Progress in NMR Spectroscopy, 88-89, 86-104, 2015.

2014

Fisher, M., Basak, R., Kalverda, A.P., Fishwick C.W.G., Turnbull, W.B. & Nelson, A., Discovery of novel FabF ligands inspired by platensimycin by integrating structure based design with diversity-oriented synthetic accessibility, Organic & Biomolecular Chemistry, 12, 486-494, 2014.

Foster, T.L., Thompson, G.S., Kalverda, A.P., Kankanala, J., Bentham, M., Wetherill, L.F., Thompson, J., Barker, A.M., Clarke, D., Noerenberg, M., Pearson, A.R., Rowlands, D.J., Homans, S.W., Harris, M., Foster, R. & Griffin, S.D.C., Structure-guided design affirms inhibitors of Hepatitis C virus p7 as a viable class of antivirals targeting virion release., Hepatology 59, 408-422, 2014.

Kalverda, A.P., Gowdy, J., Thompson, G.S., Henderson, P.J.F., Homans, S.W. & Patching S.G., TROSY NMR with a 52 kDa sugar transport protein and the binding of a small molecule inhibitor., Molecular Membrane Biology 31, 131-140, 2014.

Karamanos, T.K., Kalverda, A.P., Thompson, G.S. & Radford, S.E., Visualization of transient protein-protein interactions that promote of inhibit amyloid formation., Molecular Cell 55, 214-226, 2014.

Morin, S., Linnet, T.E., Lescanne, M., Schanda, P., Thompson G.S., Tollinger M., Teilum, K., Gagne, S., Marion, D., Griesinger, C., Blackledge, M. & d’Auvergne, E.J., Relax: the analysis of biomolecular kinetics and thermodynamics using NMR relaxation dispersion data., Bioinformatics, 30, 2219-2220, 2014.

Sarrell, C.J., Karamanos, T.K.,  White S.J., Bunka D.J., Kalverda, A.P., Thompson G.S., Barker A.M., Stockley, P.G. & Radford, S.E., Distinguishing closely related amyloid precursors using an RNA aptamer., Journal of Biological Chemistry 289, 26859-26871, 2014.

Czaljick, A., Thompson, G.S., Khan, G.N., Kalverda, A.P., Homans, S.W. & Trinick, J., 1H, 15N and 13C backbone chemical shift assignment of titin domains A59-A60 and A60 alone., Biomolecular NMR Assignments, 8, 429-433, 2014.

Hiruma-shimizu, K., Kalverda, A.P., Henderson, P.J.F., Homans, S.W. & Patching, S.G., Synthesis of uniformly deuterated n-dodecyl-beta-D-maltoside (d(39)-DDM) for solubilization of membrane proteins in TROSY NMR experiments., Journal of Labelled Compounds & Radiopharmaceuticals, 57, 737-743, 2014.

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