Affimer Applications

Crystallization chaperons

Affimers inhibit immune complex binding to FcgRIIIa with high specificity through competitive and allosteric modes of action. Robinson JI, Baxter E, Owen RL, Thomsen M, Tomlinson DC, Waterhouse MP, Win SJ, Nettleship JE, Tiede C, Foster RJ, Owens RJ, Fishwick CWG, Harris SA, Goldman A, McPherson MJ, Morgan AW. Proc Natl Acad Sci U S A. 2017 Dec 15. pii: 201707856. doi: 10.1073/pnas.1707856115.

Ubiquitin Linkage-Specific Affimers Reveal Insights into K6-Linked Ubiquitin Signaling. Martin A. Michel, Kirby N. Swatek, Manuela K. Hospenthal, David Komander. Molecular Cell, Volume 68, Issue 1, 2017,

Pages 233-246.e5,

Generation of specific inhibitors of SUMO-1– and SUMO-2/3–mediated protein-protein interactions using Affimer (Adhiron) technology. Hughes DJ, Tiede C, Penswick N, Tang AS, Trinh CH, Mandal U, Zaja KZ, Gaule T, Howell G, Edwards TA, Duan J, Feyfant E, McPherson MJ, Tomlinson DC, Whitehouse A. Sci. Signal. 14 Nov 2017:Vol. 10, Issue 505, eaaj2005. DOI: 10.1126/scisignal.aaj2005