Affimer Applications

Modulators of Protein Functions

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Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function. Heidelberger Jan B., Voigt Andrea, Borisova Marina E., Petrosino Giuseppe, Ruf Stefanie, Wagner Sebastian A, Beli Petra. EMBO rep., 2018:19 (4):1469-221X. doi:10.15252/embr.201744754

Generation of specific inhibitors of SUMO-1– and SUMO-2/3–mediated protein-protein interactions using Affimer (Adhiron) technology. Hughes DJ, Tiede C, Penswick N, Tang AS, Trinh CH, Mandal U, Zaja KZ, Gaule T, Howell G, Edwards TA, Duan J, Feyfant E, McPherson MJ, Tomlinson DC, Whitehouse A. Sci. Signal. 14 Nov 2017:Vol. 10, Issue 505, eaaj2005. DOI: 10.1126/scisignal.aaj2005 

Ubiquitin Linkage-Specific Affimers Reveal Insights into K6-Linked Ubiquitin Signaling. Martin A. Michel, Kirby N. Swatek, Manuela K. Hospenthal, David Komander. Molecular Cell, Volume 68, Issue 1, 2017, Pages 233-246.e5,