Applications
Amyloid formation
Pashley, C.L., Hewitt, E.W. & Radford, S.E., Comparison of the aggregation of homologous b2-microglobulin variants reveals protein solubility as a key determinant of amyloid formation., Journal of Molecular Biology, 428, 631-643, 2016.
Karamanos, T., Pashley, C.P., Kalverda, A.P., Thompson, G.S., Mayzel, M., Orekhov, V.Y. & Radford, S.E., A population shift between sparsely-populated folding intermediates determines amyloidogenicity., Journal of the American Chemical Society, 138, 6271-6280, 2016.
Tipping, K.W., Karamanos, T.K., Jakhria, T., Ladanza, M.G., Goodchild, S.C., Tuma, R., Ranson, N.A., Hewitt, E.W. & Radford, S.E., pH induced molecular shedding drives the formation of amyloid fibril derived oligomers., Proceedings of the National Academy of Sciences of the United States of America, 112, 5691-5696, 2015.
Karamanos, T.K, Kalverda, A.P. Thompson, G.S. & Radford, S.E., Mechanisms of amyloid formation revealed by solution NMR., Progress in NMR Spectroscopy, 88-89, 86-104, 2015.
Karamanos, T.K., Kalverda, A.P., Thompson, G.S. & Radford, S.E., Visualization of transient protein-protein interactions that promote of inhibit amyloid formation., Molecular Cell 55, 214-226, 2014.
Sarrell, C.J., Karamanos, T.K., White S.J., Bunka D.J., Kalverda, A.P., Thompson G.S., Barker A.M., Stockley, P.G. & Radford, S.E., Distinguishing closely related amyloid precursors using an RNA aptamer., Journal of Biological Chemistry 289, 26859-26871, 2014.
Eichner, T., Kalverda, A.P., Thompson, G.S., Homans, S.W. & Radford, S.E., Conformational conversion during amyloid formation at atomic resolution, Molecular Cell, 41, 161-172, 2011.
Woods, L.A., Platt, G.W., Hellewel, A.L., Hewitt, E.W., Homans, S.W., Ashcroft, A.E. & Radford, S.E., Ligand binding to distinct states diverts aggregation of an amyloid forming protein., Nature Chemical Biology, 7, 730-739, 2011.
Eichner, T. & Radford, S.E., Understanding the complex mechanisms of beta(2)-microglobulin amyloid assembly, FEBS Journal, 278, 3868-3883, 2011.
Platt, G.W., Xue, W.F., Homans, S.W. & Radford, S.E., Probing dynamics within amyloid fibrils using a novel capping method., Angewandte Chemie-International Edition, 48, 5705-5707, 2009.
Routledge, K.E., Tartaglia, G.G., Platt, G.W., Vendruscolo, M. & Radford, S.E., Competition between intramolecular and intermolecular interactions in an amyloid forming protein., Journal of Molecular Biology, 389, 776-786, 2009.
Platt, G.W., Routledge, K.E., Homans, S.W. & Radford, S.E., Fibril growth kinetics reveal a region of beta(2)-microglobulin important for nucleation and elongation of aggregation., Journal of Molecular Biology, 378, 251-263, 2008.
Jahn, T.R., Parker, M.J., Homans, S.W. & Radford, S.E., Amyloid formation under physiological conditions proceeds via a native-like folding intermediate, Nature Structural & Molecular Biology, 13, 195-201, 2006.