Cardiovascular research themes
Cardiac remodelling and repair
Our work in this area covers the processes of cardiac remodelling and repair in health and disease. Cardiac adaptions through remodelling and repair occur at multiple levels and throughout life. One highly-contested area of research is the extent of myocardial regeneration that takes place following myocardial damage, and the role of stem or progenitor cells in this.
A broad combination of approaches underpins our research: stem and progenitor cell biology; cardiovascular adaptations across the lifespan; super-resolution imaging of molecular changes in cardiac maintenance and disease; computational models of disease. We use a range of techniques from the molecular level, through cellular assays, to measurement of electrical activity in the intact heart using optical mapping.
View a list of academics within Cardiac Remodelling and Repair
View a list of postdoctoratal researchers within Cardiac Remodelling and Repair
Key researchers in the area
|
Name |
Area of expertise |
| Dr Mike Colman University Academic Fellow |
Remodelling of channel kinetics/expression vs cellular and organ structure: relative contributions to impaired contraction and arrhythmia; computational modelling |
|
Professor John Colyer |
Developing antibody probes for medical diagnostic applications (cardiorenal) and to understand pathological and physiological remodelling of the heart |
|
Dr Sue Deuchars |
Spinal cord; neurogenesis; autonomic neuroscience; neuromodulation; electrophysiology; imaging; microneurography |
|
Dr Izzy Jayasinghe |
Using new super-resolution microscopy tools to observe pathological and physiological remodelling and reorganisation of cellular structures in the heart at the single-protein scale |
| Dr Matthew Lancaster Lecturer in Exercise Physiology |
Structural and electrical remodeling of the heart with ageing; structural and electrical remodeling of the heart with exercise training |
| Dr Andrew Smith Lecturer |
Cardiovascular stem and progenitor cells; cell differentiation and function; gene and protein analyses |
| Professor Ed White Professor in Cardiac Physiology |
Investigation of the changes in cardiac structure, mechanical and electrical activity in response to heart failure and the beneficial effects of exercise on these factors |