Beatrice Filippi

Beatrice Filippi

Beatrice Filippi

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I joined the University of Leeds in August 2016 to work on insulin signalling in the brain. My laboratory studies how insulin in a specific area of the brain called the dorsal vagal complex modulates glucose metabolism and feeding behaviour in normal, obese and diabetic rodent models.

Ageing- dependent metabolic changes and brain insulin resistance: We study insulin sensing in the brain and how a specific area of the brain, the Dorsal Vagal Complex (DVC) senses insulin to regulate metabolic function (e. g. feeding behaviour, glucose metabolism). High fat diet feeding causes insulin resistance and impairs the ability of the brain to control metabolic functions. This, in the long run, can cause the development of diabetes. We are investigating the molecular mechanism that trigger insulin resistance in the brain with the idea to target the brain and ameliorate the whole-body disease conditions. With Ageing we tend to become more insulin resistance and this can affect our ability to control metabolic functions. Understanding the mechanism is the first step in developing prevention strategies and treatments.